国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (4): 388-390.

• 综述 • 上一篇    下一篇

多囊卵巢综合征与甲状腺功能减退关系的研究进展

成海英, 高天旸   

  1. 510317 广州,南华大学教学医院广东省第二人民医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-08-15 发布日期:2012-08-15

Advances About the Relationship Between Polycystic Ovarian Syndrome and Hypothyroidism

CHENG Hai-ying，GAO Tian-yang   

  1. Department of Reproduction，Teaching Hospital of South China University，the Second People's Hospital of Guangdong Province，Guangzhou 510317，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-08-15 Online:2012-08-15

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摘要： 多囊卵巢综合征（PCOS）是一种发病多因性、病理生理和临床表现多样的内分泌综合征。研究显示，PCOS患者的甲状腺疾病发病率增高。早期的学者主要是对神经内分泌和免疫方面进行研究，认为PCOS可影响垂体-甲状腺功能轴，并使患者免疫系统受到过度刺激。近期新的研究在分子生物学水平上取得突破，认为PCOS患者的促性腺激素释放激素受体基因变异与甲状腺功能有关。同时，甲状腺功能的改变也可能影响PCOS患者排卵功能及胰岛素敏感性等。

关键词: 多囊卵巢综合征, 甲状腺功能减退症, 受体, 促性腺激素, 甲状腺素, 胰岛素抗药性

Abstract: Polycystic ovarian syndrome（PCOS） is a heterogeneous and polymorphic endocrine disease. Studies have
shown that patients with PCOS had a higher incidence of thyroid disease. Earlier studies mainly consider that women with PCOS can affect the pituitary-thyroid axis，and their immune system was over-stimulated . Recently，new research reveals that genetic variation in the 3′-untranslated region of gonadotropin-releasing hormone receptor is associated with thyroid function in PCOS patients. At the same time， changes in thyroid function can affect ovulation disorders and insulin resistance in women with PCOS.

Key words: Polycystic ovary syndrome, Hypothyroidism, Receptors, gonadotropin, Thyroxine, Insulin resistance