国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (5): 373-376.

• 综述 • 上一篇    下一篇

血管紧张素Ⅱ及其Ⅰ型受体与妇科肿瘤

张铭娜;曲芃芃   

  1. 300070 天津医科大学(张铭娜)；天津市中心妇产科医院(曲芃芃)
  • 收稿日期:2008-12-26 修回日期:1900-01-01 出版日期:2009-10-15 发布日期:2009-10-15

The Progression on the Relationship Between AngⅡ, AT1R and Gynecological Oncology

ZHANG Ming-na;QU Peng-peng   

  1. Tianjin Medical University, Tianjin 300070, China （ZHANG Ming-na）; Tianjin Central Gynecology & Obstetric Hospital, Tianjin 300052, China（QU Peng-peng）
  • Received:2008-12-26 Revised:1900-01-01 Published:2009-10-15 Online:2009-10-15

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摘要： 血管紧张素Ⅱ（AngⅡ）是肾素－血管紧张素－醛固酮系统（RAS）的主要活性成分，在人体血压与水-电解质平衡调节过程中起着关键作用。近年研究发现，除循环中存在RAS外，在一些恶性肿瘤组织中也同样存在着RAS的局部活化，在局部组织中AngⅡ通过与其Ⅰ型受体（AT1R）结合参与肿瘤的发生、发展、血管生成等，而阻断AngⅡ或AT1R有望成为肿瘤治疗的新靶点。就AngⅡ及AT1R与妇科肿瘤关系研究进展综述。

关键词: 血管紧张素Ⅱ, 血管紧张素ⅡⅠ型受体, 妇科肿瘤

Abstract: AngiotensinⅡ（AngⅡ） is the main active component of the Renin-Angiotensin-aldosterone
system（RAS） and plays an important role in human blood pressure and liquid-electrolyte balance. Recently years, studies indicated that, RAS does not only exist in the blood circulation but also in some malignant tumor tissues, and in region tissues, and AngⅡparticipates tumor genesis, development and angiogenesis through binding to the AT1R. As a result, blocking AngⅡ or Angiotensin Ⅱ type 1 receptor （AT1R） may be a new target for tumor therapy. This article intents to summarize the progression on the relationship between AngⅡ, AT1R and gynecological oncology.

Key words: AngiotensinⅡ, Angiotensin Ⅱ type 1 receptor, Gynecological oncology