国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (1): 64-67.

• 综述 • 上一篇    下一篇

卵巢癌诊断中恶性风险指数的可改良空间

吴晓慧;李卫平;狄文   

  1. 200001 上海交通大学医学院附属仁济医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-15 发布日期:2010-02-15
  • 通讯作者: 李卫平

Improved Space of Risk of Malignancy Index in Diagnosis of Ovarian Tumor

WU Xiao-hui;LI Wei-ping;Di Wen   

  1. Department of Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-02-15 Online:2010-02-15
  • Contact: LI Wei-ping

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摘要： 在卵巢癌诊断中，恶性风险指数综合了绝经状态、超声形态及血清CA125 这3种高危因素，弥补了单项指标的不足，提高了诊断的敏感性和特异性。但仍有一些不足和滞后，需进一步改良且具有很大的改良空间。适当增加新的有意义的肿瘤标志物，如人附睾蛋白、间皮素、骨桥蛋白等，可与血清CA125互补，提高卵巢癌检出率；合理引入超声诊断的新指标，如阻力指数、搏动指数等, 并结合遗传、环境等易感因素及患者临床症状，可提高恶性风险指数诊断效能，检出更多的早期卵巢癌。
【关键词】 恶性风险指数； 人附睾蛋白； 间皮素； 骨桥蛋白； 阻力指数； 搏动指数

关键词: 恶性风险指数, 人附睾蛋白, 间皮素, 骨桥蛋白, 阻力指数, 搏动指数

Abstract: The risk of malignancy index was developed depending on menopausal state, ultrasound findings and serum CA125，and the combination of three high risk factors make up for the deficiency of each other in diagnosis of ovarian tumor, hence the diagnostic sensitivity and specificity of ovarian cancer have been improved. However, the inadequacy and hysteresis of the risk of malignancy index show up at the same time. It need to be improved and it has wide improved space. Adding some new significant tumor markers（such as human epididymis protein 4, mesothelin and osteopontin） to serum CA125 could improve the isolating rate of ovarian cancer. Combined with new indices of ultrasonic diagnosis（such as resistent index and pulsatility index）, predisposing factor of heredity or environment and clinical symptom of ovarian cancer, the diagnostic value of risk of malignancy index can be improved, thus more early carcinoma has been detected.

Key words: Risk of malignancy index, Human epididymis protein 4, Mesothelin, Osteopontin, Resistent index, Pulsatility index