国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (1): 60-63.

• 综述 • 上一篇    下一篇

微小RNA在卵巢癌中的研究进展

史蔚;万小平   

  1. 200080 上海，上海交通大学附属第一人民医院妇产科（史蔚）;上海交通大学附属国际和平妇幼保健院（万小平）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-15 发布日期:2010-02-15
  • 通讯作者: 万小平

New Discoveries about MicroRNA in Ovarian Cancer

SHI Wei;WAN Xiao-ping   

  1. Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai 200080, China（SHI Wei）；Shanghai International Peace Maternity and Children Health Care Hospital, Shanghai 200030, China（WAN Xiao-ping） Corresponding author: WAN Xiao-ping, E-mail：wanxiaoping61@126.com
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-02-15 Online:2010-02-15
  • Contact: WAN Xiao-ping

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摘要： 微小RNA（microRNA，miRNA）是一种内源性非编码小RNA，其在转录后水平负调节靶基因的表达。一个肿瘤相关的微小RNA通常可以同时调节几个癌基因和抑癌基因的表达水平，因此miRNA与肿瘤的发生、发展和预后有着密切的联系。研究发现，一些miRNA在正常卵巢组织和上皮性卵巢癌组织中表达水平明显不同，其表达谱可作为潜在的肿瘤标志物对卵巢癌进行早期诊断和预后判断。此外，对某些在卵巢癌中调节异常的miRNA靶基因的探索，不但可有助于了解卵巢癌的发病机制，同时也可为卵巢癌治疗提供新靶点。

关键词: 微小RNA, 卵巢癌, 生物学标记, 肿瘤相关的微小RNA

Abstract: microRNAs（miRNAs）, a kind of small non-protein-coding RNAs, can negatively regulate the
expression of target gene at the post-transcriptional level. One oncogenic miRNA can usually regulate the expression level of several oncogenes and tumor suppressor genes simultaneously. Hence, miRNAs have closely relationship with oncogenesis, development and prognosis of tumor. Studies have indicated that the expression level of some miRNAs in epithelial ovarian cancer tissue is significantly different from that in normal ovarian tissue. And the miRNA expression profiling can be used as a potential tumor marker for the early diagnosis and the estimation of prognosis in ovarian cancer. In addition, the inspection of the target genes of those deregulated miRNAs in ovarian cancer can help to understand the mechanism of oncogenesis of ovarian cancer, which might also provide new targets for the therapy of ovarian cancer.

Key words: microRNA, Ovarian cancer, Biomarker, Oncogenic microRNA