微小RNA在子宫内膜异位症中的研究进展

doi:10.12280/gjfckx.20200903

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis,EMs）是一种极具复发性和侵袭性的良性疾病,严重影响育龄女性的生活质量。目前临床上缺乏有效的生物标志物,是造成诊断延迟的重要原因之一。随着疾病的进一步进展,EMs给患者带来严重的健康损害和经济负担。目前,腹腔镜检查是确诊EMs的方法,但因其有创、手术并发症及费用昂贵等特点,限制了临床应用。探索敏感度和特异度均佳的生物标志物对于EMs的无创性早期诊断至关重要。微小RNA（microRNA,miRNA）是一类非编码小分子RNA,具有高度的组织特异性和稳定性,近年研究表明miRNA可作为EMs诊断的潜在生物标志物,早期识别有助于对患者的及时诊断和优化治疗。综述miRNA在EMs中的研究进展。

关键词: 子宫内膜异位症, 微RNAs, 生物学标记,药理学, 不育,女（雌）性, 血清, 血浆

Abstract:

Endometriosis(EMs) is a highly recurrent and invasive benign disease, which seriously affects the quality of life of female between puberty and menopause. The lack of effective biomarkers in clinic is one of the important causes leading to the delay of diagnosis. With the progress of the disease, it brings serious health damage and economic burden to patients. At present, laparoscopy is the method for the diagnosis of EMs, but its application in clinic is limited because of its invasiveness, operative complications and high cost. The exploration of biomarkers with good sensitivity and specificity is very important for the non-invasive early diagnosis of EMs. MicroRNA (miRNA) is a kind of non-coding small molecule RNA, with high tissue specificity and stability. Recent studies have shown that miRNA can be used as a potential biomarker for the diagnosis of EMs. Early recognition is helpful for timely diagnosis and treatment of patients. This article reviews the research progress of miRNA in EMs.

Key words: Endometriosis, MicroRNAs, Biomarkers,pharmacological, Infertility,female, Serum, Plasma

洪雅艺, 汤小晗, 卢美松. 微小RNA在子宫内膜异位症中的研究进展[J]. 国际妇产科学杂志, 2021, 48(3): 277-280.

HONG Ya-yi, TANG Xiao-han, LU Mei-song. Research Progress of MicroRNA in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 277-280.

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