血管内皮生长因子及其相关微小RNA在子宫内膜异位症中的研究进展

doi:10.12280/gjfckx.20200905

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis,EMs）是一种常见的妇科良性疾病,但在行为学上却有类似恶性肿瘤的特点,如细胞远处转移、侵袭、种植和新生血管形成等,其发病机制有多种学说,但具体机制仍在不断研究中。子宫内膜异位病灶的存活和生长依赖足够的血液供应,血管形成是关键的环节之一。血管内皮生长因子（VEGF）是血管内皮细胞特异性的肝素结合生长因子,可诱导血管新生,是子宫内膜中最常见的促血管生成因子。微小RNA（miRNA）是一类短小的内源性RNA,通过与靶向信使RNA的核苷酸序列结合,在基因表达调控中发挥重要作用。许多研究表明miRNA在EMs中存在差异性表达,并参与EMs发病的多个环节。近年来,越来越多的研究表明miRNA通过调控VEGF的表达,影响EMs血管生成。分析VEGF及其相关miRNA在EMs发生发展中的作用,探讨EMs的发病机制并寻找EMs治疗的新靶点。

关键词: 子宫内膜异位症, 血管内皮生长因子, 微小RNAs, MiR-17-5p, MiR-126

Abstract:

Endometriosis (EMs) is a common gynecological benign disease, but it has characteristics similar to malignant tumors in behavior, such as distant cell metastasis, invasion, implantation, neovascularization etc. Its pathogenesis has many theories, but its specific mechanism is still under continuous study. The survival and growth of endometriotic lesions depend on adequate blood supply, and angiogenesis is one of the key links. Vascular endothelial growth factor (VEGF) , a heparin-binding growth factor specific for vascular endothelial cells, induces angiogenesis and is the most common proangiogenic factor in the endometrium. MicroRNA(miRNA), a class of short endogenous RNAs, plays an important role in the regulation of gene expression by binding to complementary nucleotide sequences of the targeted messenger RNA. Many studies have shown that miRNA are differentially expressed in EMs and are involved in multiple links in the pathogenesis of EMs. In recent years, more and more studies have shown that miRNA affect angiogenesis in EMs by regulating the expression of VEGF. By analyzing the role of VEGF and its related miRNA in the development of EMs, the pathogenesis of EMs was explored and new targets for EMs treatment were sought.

Key words: Endometriosis, Vascular endothelial growth factors, MicroRNAs, MiR-17-5p, MiR-126

刘娜娜, 汤小晗, 卢美松. 血管内皮生长因子及其相关微小RNA在子宫内膜异位症中的研究进展[J]. 国际妇产科学杂志, 2021, 48(3): 272-276.

LIU Na-na, TANG Xiao-han, LU Mei-song. Research Progress of Vascular Endothelial Growth Factor and Related MicroRNA in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 272-276.

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