空间转录组技术在子宫内膜异位症免疫微环境研究中的应用前景

doi:10.12280/gjfckx.20230734

国际妇产科学杂志 ›› 2024, Vol. 51 ›› Issue (1): 82-86.doi: 10.12280/gjfckx.20230734

• 普通妇科疾病及相关研究:综述 • 上一篇下一篇

空间转录组技术在子宫内膜异位症免疫微环境研究中的应用前景

许泽玫红, 杨如玉, 吴琼, 吕艺, 梁炎春^△()

510080 广州，中山大学中山医学院（许泽玫红，吕艺）;中山大学附属第一医院妇产科&广东省妇产疾病临床医学研究中心（杨如玉，吴琼，梁炎春）

收稿日期:2023-09-18 出版日期:2024-02-15 发布日期:2024-02-19
通讯作者: 梁炎春 E-mail:lyanchun@mail.sysu.edu.cn
作者简介:^△审校者
基金资助:
国家自然科学基金(82071618);广东省科技创新战略专项资金（省基础与应用基础研究基金自然科学基金）(2021A1515012615);广州市基础研究计划基础与应用基础研究项目（一般项目）(202201011555);中山大学大学生创新训练计划项目(202310710);中山大学大学生创新训练计划项目(202310704);广东省本科高校在线开放课程指导委员会研究课题(2022ZXKC004)

The Potential Application of Spatial Transcriptome Technology in the Research of Immune Microenvironment of Endometriosi

XU Ze-mei-hong, YANG Ru-yu, WU Qiong, LYU Yi, LIANG Yan-chun^△()

Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China (XU Ze-mei-hong, LYU Yi); Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University & Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou 510080, China (YANG Ru-yu, WU Qiong, LIANG Yan-chun)

Received:2023-09-18 Published:2024-02-15 Online:2024-02-19
Contact: LIANG Yan-chun E-mail:lyanchun@mail.sysu.edu.cn

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis，EMs）是育龄期妇女常见疾病，发病机制尚未明确。该病有着独特的类肿瘤表现，由细胞成分（如巨噬细胞、自然杀伤细胞和T淋巴细胞等）和非细胞成分共同构成的免疫微环境在异位病灶的发生发展中起重要作用。空间转录组技术作为一项近年来研究多种细胞间相互作用以及细胞空间连接的新技术，不仅可以描绘免疫微环境的整体图景，还可以用于探究免疫细胞在微环境中的动态发展和空间特异性。因此，空间转录组技术为EMs免疫微环境的深入探究提供了新技术和新思路。

关键词: 子宫内膜异位症, 免疫系统, 白细胞, 单核, 细胞因子类, 免疫微环境, 空间转录组

Abstract:

Endometriosis is a common disease in women of childbearing age, and its pathogenesis has not yet been clarified. The disease has unique tumor-like characteristic, and the immune microenvironment, which consists of both cellular components (e.g., macrophages, natural killer cells, and T-lymphocytes) and non-cellular components, plays an important role in the development of ectopic lesions. Spatial transcriptome technology, as a new technology to study multiple cellular interactions and cellular spatial connectivity in recent years, can not only provides an overall view of the immune microenvironment, but also be used to explore the dynamic development and spatial specificity of immune cells in the microenvironment. Therefore, spatial transcriptome technology provides a new technique and new insights for in-depth investigation of the immune microenvironment in endometriosis.

Key words: Endometriosis, Immune system, Leukocytes, mononuclear, Cytokines, Immune microenvironment, Spatial transcriptome

许泽玫红, 杨如玉, 吴琼, 吕艺, 梁炎春. 空间转录组技术在子宫内膜异位症免疫微环境研究中的应用前景[J]. 国际妇产科学杂志, 2024, 51(1): 82-86.

XU Ze-mei-hong, YANG Ru-yu, WU Qiong, LYU Yi, LIANG Yan-chun. The Potential Application of Spatial Transcriptome Technology in the Research of Immune Microenvironment of Endometriosi[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 82-86.

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空间转录组技术在子宫内膜异位症免疫微环境研究中的应用前景

The Potential Application of Spatial Transcriptome Technology in the Research of Immune Microenvironment of Endometriosi

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