HOXA10及相关微小RNA在子宫内膜异位症中的研究进展

doi:10.12280/gjfckx.20200904

摘要/Abstract

摘要：

子宫内膜异位症（EMs）是一种世界范围内普遍存在的妇科疾病,其具体的发病机制至今尚未明确。越来越多的证据表明EMs是一种表观遗传学疾病,通过DNA甲基化和微小RNA（microRNA,miRNA）调控等参与EMs的发生发展。同源盒基因A10（HOXA10）是DNA甲基化靶向调控的基因之一,不仅在雌性生殖系统中发挥着重要作用,且其异常表达及异常甲基化模式与EMs发病及不孕密切相关。miRNA是一类由大约22个核苷酸组成的高度保守的非编码调控RNA,通过调控子宫内膜细胞黏附、侵袭及血管生成等多种病理生理过程影响着EMs,但其确切作用机制尚未完全明确。近年研究发现HOXA10与miRNA在EMs患者中的表达存在相关性,miRNA能够异常调控HOXA10的表达进而促进EMs的发生发展。就HOXA10及相关miRNA在EMs中的研究进展进行综述,以期为进一步阐明EMs发病可能的分子机制及其临床诊治提供新的思路。

关键词: 子宫内膜异位症, 表观遗传学, 微小RNA, DNA甲基化, 同源盒基因A10

Abstract:

Endometriosis (EMs) is a widespread gynecological disease in the world, and its specific pathogenesis is still unclear. More and more evidence shows that EMs is an epigenetic disease, which participates in the occurrence and development of EMs through DNA methylation and microRNA (miRNA) regulation. Homologous heterobox gene A10 (HOXA10) is one of the genes targeted by DNA methylation, which not only plays an important role in the female reproductive system, but also its abnormal expression and abnormal methylation pattern are closely related to the onset and infertility of EMs. MiRNA is a highly conserved non-coding regulatory RNA composed of about 22 nucleotides, which can influence endometriosis by regulating various pathophysiological processes such as adhesion, invasion, and angiogenesis of endometrial cells, but its exact mechanism is not completely clear. In recent years, it has been found that there is a correlation between HOXA10 and miRNA expression in EMs patients, and miRNA can abnormally regulate the expression of HOXA10 and promote the occurrence and development of EMs. This article reviews the research progress of HOXA10 and related miRNA in EMs, aim to provide new ideas for elucidating the possible molecular mechanism of endometriosis and its clinical diagnosis and treatment.

Key words: Endometriosis, Epigenetics, MicroRNAs, DNA methylation, Homologous box gene A10

李崑瑜, 汤小晗, 卢美松. HOXA10及相关微小RNA在子宫内膜异位症中的研究进展[J]. 国际妇产科学杂志, 2021, 48(1): 10-14.

LI Kun-yu, TANG Xiao-han, LU Mei-song. Research Progress of HOXA10 and Related MiRNA in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 10-14.

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