国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (5): 466-469.

• 论著 • 上一篇    下一篇

人附睾蛋白4对子宫内膜癌的风险评估研究

张双革   

  1. 300100 天津市中心妇产科医院检验科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-10-15 发布日期:2013-10-15

Research of Tumor Markers for Endometrial Cancer Risk Evaluation

ZHANG Shuang-ge   

  1. Department of Laboratory Medicine, Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-10-15 Online:2013-10-15

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摘要： 目的：探讨血清人附睾蛋白4（HE4）、癌抗原125（CA125）对子宫宫体疾病患者患子宫内膜癌风险的评估价值。方法：采用电化学发光法检测453例子宫肌瘤患者、126例子宫腺肌病患者、26例子宫内膜增生患者、10例子宫内膜息肉患者、212例子宫内膜癌患者以及72例体检正常妇女血清HE4和CA125水平。结果：血清HE4在子宫内膜癌组的表达水平高于其他各组，差异有统计学意义（均P＜0.01）；血清CA125在子宫腺肌病组的表达水平高于其他各组，差异有统计学意义（均P=0.000）；子宫内膜癌患者血清HE4表达水平与国际妇产科联盟（FIGO）分期呈正相关（rs=0.538，P=0.000）；HE4与CA125联合检测子宫内膜癌的敏感度比单独HE4检测的敏感度高。结论：单独血清HE4以及与CA125联合检测对子宫内膜癌早期诊断、分期及预后评估都有一定意义，可以作为诊断子宫内膜癌的重要指标。

关键词: 子宫内膜肿瘤, CA-125抗原, 诊断, 人附睾蛋白4

Abstract: Objective：To explore serum human epididymis protein 4 （HE4），cancer antigen 125 （CA125） for uterine endometrial cancer risk assessment. Methods：With electroluminescent assay in 453 patients with myoma of uterus，126 cases of adenomyosis，26 cases of endometrial hyperplasia patients，10 cases of endometrial polyps patients，212 cases of endometrial cancer patients and 72 cases of healthy women of serum HE4 and CA125 levels. Results：The serum level of HE4 expression in endometrial carcinoma were higher than that of the other groups，the difference was statistically significant （P＜0.01）. The serum level of CA125 expression in adenomyosis were higher than that of the other groups，the difference was statistically significant （P=0.000）. Endometrial carcinoma patients serum HE4 expression level and FIGO stag were a significant positive correlation （rs=0.538，P=0.000）. HE4 and CA125 combined detection of endometrial cancer sensitivity were higher than single HE4 detection sensitivity. Conclusions：Single serum HE4 and CA125 detection has a certain significance to the early diagnosis，staging and prognosis of endometrial carcinoma，which can be used as an important index for the diagnosis of endometrial cancer.

Key words: Endometrial neoplasms, CA-125 antigen, Diagnosis, Human epididymis protein 4