国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (1): 32-34.

• 综述 • 上一篇    下一篇

雌激素防治阿尔茨海默病的作用机制

饶艳秋，王文君   

  1. 200093 上海，复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 王文君

The Mechanism of Prevention and Treatment of Estrogen in Alzheimer′s Disease

RAO Yan-qiu，WANG Wen-jun   

  1. Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200093，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-02-15 Online:2014-02-15
  • Contact: WANG Wen-jun

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摘要： 随着当今社会老龄化日趋明显，阿尔茨海默病（Alzheimer′s disease，AD）的发病率明显上升，对AD的治疗也越发重要。越来越多的研究表明，雌激素对AD的防治具有一定作用，雌激素能降低脑内β-淀粉样蛋白（Aβ）水平、抑制tau蛋白过度磷酸化、提高胆碱能神经元活性、调节载脂蛋白表达、抑制脑内氧化应激、增加脑血流、减轻炎症反应、维持钙离子平衡。主要从AD发病机制的角度对雌激素防治AD的作用机制进行概述，为今后的临床治疗提供指导。

关键词: 阿尔茨海默病, 雌二醇, 淀粉样β蛋白前体, tau蛋白质类, 治疗

Abstract: Going with the social olden，the incidence rate of Alzheimer′s disease increase evidently，the treatment become more important. More and more studies show that estrogen can prevent Alzheimer′s disease. Estrogen can lower brain Aβ content, suppress tau phosphorylation, improve the acetylcholinesterase activity, regulate apolipoprotein-E expression, increase cerebral blood, decrease inflammation and maintain the balance of calcium. This review recapitulates the important role of estrogen in the mechanism of the prevention of AD from the angle of the pathogenesis of AD，in order to provide basis for clinical treatment.

Key words: Alzheimer disease, Estradiol, Amyloid beta-protein precursor, Tau proteins, Therapy