国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (2): 201-203.

• 论著 • 上一篇    下一篇

子宫内膜息肉的性状与异常子宫出血的关系及对息肉恶变的影响

胡小美,关铮,周丽,李洁,范军振
  

  1. 100853 北京,中国人民解放军总医院妇产科(胡小美,关铮,李洁),病理科(范军振);中国人民解放军477医院妇产科(周丽)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-15 发布日期:2015-04-15
  • 通讯作者: 关铮

Explore the Relationship between Endometrial Polyp Characteristics and Abnormal Uterine Bleeding and the Influence to Its Malignancy

HU Xiao-mei,GUAN Zheng,ZHOU Li,LI Jie,FAN Jun-zhen   

  1. Department of Obstetrics and Gynecology(HU Xiao-mei,GUAN Zheng,LI Jie),Department of Pathology(FAN Jun-zhen),Chinese PLA General Hospital,Beijing 100853,China;Department of Obstetrics and Gynecology,Chinese PLA 477 Hospital,Xiangyang 441003,Hubei Province,China(ZHOU Li)
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-15 Online:2015-04-15
  • Contact: GUAN Zheng

摘要: 目的:探讨子宫内膜息肉性状与异常子宫出血间的关系及不同因素对息肉潜在恶变及恶变的影响。方法:回顾性收集2010年1月—2013年6月在中国人民解放军总医院妇科行宫腔镜检查且诊断为子宫内膜息肉的住院患者754例,分析并总结息肉的数目、大小及与异常子宫出血的关系。将息肉患者按病理结果分为良性组与恶变或潜在恶变组,比较分析不同因素与息肉恶变及潜在恶变的关系。结果:754例子宫内膜息肉患者中,38.59%(291/754)的患者并发出血症状,多发息肉与单发息肉并发出血的概率分别为44.26%(135/305)和34.74%(156/449),差异有统计学意义(χ2=6.94,P<0.01)。449例单发息肉患者中,直径>10 mm和直径≤10 mm息肉并发出血的概率分别为38.69%(106/274)和28.57%(50/175),差异有统计学意义(χ2=4.82,P<0.05)。此外,754例子宫内膜息肉患者中,22例(2.92%)发生癌前病变,24例(3.18%)发生癌变。经Logistic回归分析,绝经期、息肉直径>10 mm、息肉多发、异常子宫出血4个因素对息肉恶变的发生有显著的影响(P<0.01)。结论:当息肉直径>10 mm或多发时,患者出血概率增大。异常子宫出血、息肉直径>10 mm、息肉多发、绝经期等是息肉恶变的危险因素。

关键词: 子宫内膜, 息肉, 子宫出血, 绝经期, 危险因素

Abstract: Objective: To evaluate the relationship between endometrial polyp(EP) characteristics and abnormal uterine bleeding, and analyze the influence to its malignancy. Methods:Retrospectively collect cases from January 2010 to June 2013 who received hysteroscopy and confirmed diagnosis as endometrial polyps in our hospital. Review and summarize polyp number and size of each case, and analyze the relationship between them and abnormal uterine bleeding. By pathology results, the polyp patients were divided into benign polyp and potentially malignant or malignant polyps. Analyze the relationship between the various risk factors associated with malignant polyps and malignant potential. Results:Of the included 754 cases, 38.59%(291/754) of patients with bleeding symptoms. Probability of multiple polyps and solitary polyp with bleeding were 44.26%(135/305) and 34.74%(156/449), and the difference was statistically significant(χ2=6.94,P<0.01). In 449 patients with solitary polyp, probability of large(size>10 mm) and small polyp(size <10 mm) with bleeding were 38.69%(106/274) and 28.57%(50/175), and the differene was statistically significant(χ2=4.82,P<0.05). Among polyp patients, 2.92%(22/754) of precancerous lesions, 3.18%(24/754) of cancerous. By Logistic analysis, the factors of postmenopause, polyps diameter>10 mm, multiple polyps and merging bleeding symptoms have a significant influence on precancerous and cancerous polyps(P<0.01). Conclusions:Bigger(>10 mm) or multiple polyps may be the risk factors and have a higher probability of abnormal uterine bleeding manifestations. Menopause,polyp diameter>10 mm, multiple polyps, abnormal uterine bleeding are risk factors for malignant polyps.

Key words: Endometrium, Polyps, Uterine hemorrhage, Menopause, Risk factors