国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (5): 503-506.

• 综述 • 上一篇    下一篇

子宫内膜异位症疼痛与缓激肽B1受体阻断剂的关系

张海燕, 朱芝玲   

  1. 200090 上海,复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-10-15 发布日期:2012-10-15

Relationship Between Endometriotic Pain and Antagonist of Bradykinin B1 Receptor

ZHANG Hai-yan，ZHU Zhi-ling   

  1. Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200090，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-10-15 Online:2012-10-15

PDF (PC)

4977

摘要： 子宫内膜异位症（EMs）是指有功能的子宫内膜异位在子宫腔外，疼痛是其最常见的临床症状。目前，EMs疼痛的发病机制尚不明确。缓激肽是目前已知最强的致痛剂，而缓激肽B1受体是维持炎症反应中渗出及疼痛持续发生的主要因素之一。近年对缓激肽B1受体阻断剂在炎症和疼痛等多个方面的研究发现，其不仅能抑制炎症反应，并且有明显缓解疼痛的效果。对EMs疼痛以及缓激肽B1受体阻断剂在疼痛方面的研究做一综述。

关键词: 子宫内膜异位症, 疼痛, 缓激肽, 受体, 缓激肽B1, 受体, 缓激肽B2

Abstract: Endometriosis is defined as ectopic endometrium locates outside the cavity of uterus，with pain as the most distinguish clinical manisfestation. So far，the pathogenesis of the pain in endometriosis is unclear yet. Bradykinin is the strongest algogen，and bradykinin B1 receptor is considered as one of the main factors that maintain inflammation and pain. Previous studies have revealed that bradykinin B1 receptor antagonist could effectively be used in treating inflammation and pain. Recent research progress on endometriotic pain and bradykinin B1 receptor antagonist has been reviewed in this article.

Key words: Endometriosis, Pain, Bradykinin, Receptor, bradykinin B1, Receptor