国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 402-406.

• 综述 • 上一篇    下一篇

树突状细胞与生殖道黏膜免疫

李 莉,黄丽丽   

  1. 310022 杭州,浙江省肿瘤医院(李莉);浙江大学医 学院附属妇产科医院(黄丽丽)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 黄丽丽

Mucosal Dendritic Cells in the Genital Tract Immuology

LI Li，HUANG Li-li   

  1. Department of Gynecologic Oncology，Zhejiang Cancer Hospital，Hangzhou 310022，China（LI Li）；Women’s Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China（HUANG Li-li） Corresponding author：HUANG Li-li，E-mail：fbhuanglili@163.com
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: HUANG Li-li

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摘要： 树突状细胞是机体内功能最强大的抗原提呈细胞，广泛分布于机体黏膜表面，在固有免疫应答和适应性免疫应答中发挥重要作用。女性生殖道黏膜免疫既涉及对外来病原体的免疫防御，又涉及到对同种异体的精子及半同种异体移植物（胚胎）的免疫耐受，必然具有特殊的免疫学机制。综述树突状细胞与生殖道黏膜免疫研究进展。

关键词: 树突细胞, 生殖器, 女（雌）性, 免疫, 黏膜, 孕妇, 免疫耐受

Abstract: Dendritic cells（DCs）are the most potent antigen-presenting cell（APC）and play important roles in innate immune defense as well as in adaptive immunity. The female genital tract is immunologically unique in its requirement for immunity against a wide array of pathogens and for tolerance the allogeneic sperm and the semi-allogeneic embryo. This review summarizes the latest advances in our understanding of DCs in the genital tract with respect to their subsets，lineage，and function.

Key words: Dendritic cells, Genitalia, female, Immunity, mucosal, Pregnant women