关键词: 卵巢肿瘤, 癌, 雌激素类, 孕激素类, 雄激素类, 促性腺激素, 治疗

Abstract: Ovarian cancer is one of gynecological malignant tumors which can result in a high mortality. Although many hypotheses have been introduced，such as incessant ovulation，inflammation hypothesis，stroma hypothesis， gonadotropic hormone hypothesis，androgen/progestin hypothesis，the pathogenesis of ovarian cancer is unclear. The early diagnosis of ovarian cancer is very difficult，and approximate 70% tumors are at advanced stage at the time of diagnosis. About 75% tumors will relapse after one stage of treatment，and the prognosis is poor. The remedial chemotherapy for recurrent ovarian cancer has limited effects. Epidemiology study and experiments in vivo and vitro have already demonstrated that the steroid hormone released from hypothalamus-pituitary-ovary axis could promote or inhibit the progression of ovarian cancer. Hormonotherapy has certain curative effects and only some slight side effects.This article will focus on the association between hormone （gonadotropin releasing hormone，gonadotrophin，androgen，progestin and estrogen）and their receptors and ovarian cancer，and the current situation of hormonotherapy for recurrent ovarian cancer.

Key words: Ovarian neoplasms, Carcinoma, Estrogens, Progestins, Androgens, Gonadotrophin