国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (4): 324-327.

• 综述 • 上一篇    下一篇

硫酸基转移酶家族与妇科肿瘤

管 睿,郑唯强   

  1. 200433 上海,第二军医大学第一附属医院妇产科(管 睿),病理科(郑唯强)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-08-15 发布日期:2011-08-15
  • 通讯作者: 管 睿

SULT Family and Gynecological Tumors

GUAN Rui，ZHENG Wei-qiang   

  1. Department of Obstetrics and Gynecology，First Affiliated Hospital，Second Military Medical University，Shanghai 200433，China（GUAN Rui）；Department of Pathology，First Affiliated Hospital，Second Military Medical University，Shanghai 200433，China（ZHENG Wei-qiang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-08-15 Online:2011-08-15
  • Contact: GUAN Rui

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摘要： 硫酸基转移酶（sulfotransferase，SULT）是机体催化多种内源性和外源性复合物硫酸化代谢的关键酶。人类SULT基因家族主要有：SULT1，SULT2，SULT4和SULT6，已确定的家族成员至少有13个。人体内能催化雌激素硫酸化的SULT主要包括SULT1E1，SULT1A1，SULT1A3和SULT2A1，其中SULT1E1对雌激素的亲和力最强，与雌激素的代谢密切相关。近年研究发现，子宫肌瘤、子宫内膜癌等妇科肿瘤中SULT1E1和SULT1A1表达异常，并发现SULT1 E1和SULT1 A1基因多态性与妇科肿瘤易感性相关。

关键词: 催化作用, 基因, 生殖器肿瘤, 女（雌）性, 多态性, 单核苷酸, 硫酸基转移酶

Abstract: Sulfonation is an important reaction in the metabolism of numerous exogenous and endogenous compounds. A supergene family of enzymes called sulfotransferases（SULTs）catalyze this reaction. In humans four SULT families，SULT1，SULT2，SULT4 and SULT6，have been identified that containning at least thirteen distinct members. Part of the SULT family members involved in metabolism of sex hormones sulfation. Research indicated abnormal SULT1A1 and SULT1E1 gene expression in uterine fibroids,endometrial cancer and other gynecological tumors and recent studies have begun to suggest roles of SULT1A1 and SULT1E1 polymorphism acting in gynecological tumors susceptibility.

Key words: Catalysis, Genes, Genital neoplasms, female, Polymorphism, single nucleotide