PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用

doi:10.12280/gjfckx.20250484

摘要/Abstract

摘要：

宫颈癌在我国女性恶性肿瘤中发病率位居第二，是女性癌症死亡的主要原因之一，且总体发病率呈上升趋势。目前，液基薄层细胞学检查（thin-prep cytology test，TCT）和高危型人乳头瘤病毒（high-risk human papilloma virus，HR-HPV）DNA检测是主要的宫颈癌筛查手段，但二者均存在局限性，TCT结果可重复性差且敏感度低；而HR-HPV DNA检测特异度低，可能导致过度诊疗，因此亟需更精准的筛查方案。随着DNA甲基化检测技术迅速发展，多种基因甲基化被用于宫颈癌筛查，其中配对框基因1（paired box gene 1，PAX1）/连接黏附分子3（junctional adhesion molecule 3，JAM3）双基因甲基化备受关注，有研究称其与宫颈癌细胞迁移和侵袭相关。尽管目前相关研究尚不完善，但PAX1/JAM3双基因甲基化在宫颈癌筛查和治疗领域极具潜力，联合应用PAX1/JAM3双基因甲基化，有助于优化宫颈癌筛查策略，提高临床分流准确性。综述PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用，旨在为宫颈癌筛查的精准实施和分层管理提供理论依据。

关键词: 宫颈上皮内瘤样病变, 宫颈肿瘤, DNA甲基化, 配对框基因1, 连接黏附分子3

Abstract:

Cervical cancer ranks second in the incidence of female malignant tumors in China and is one of the main causes of female cancer-related deaths. Moreover, the overall incidence showed an upward trend. Currently, the thin-prep cytology test (TCT) and high-risk human papilloma virus (HR-HPV) DNA testing are the main screening methods for cervical cancer. However, both have limitations. The TCT results have poor reproducibility and low sensitivity, while the HR-HPV DNA test has low specificity, which may lead to over-diagnosis and over-treatment. Therefore, a more accurate screening program is urgently needed. With the rapid development of DNA methylation detection technology, multiple gene methylations have been used in cervical cancer screening. Among them, the methylation of paired box gene 1 (PAX1)/junctional adhesion molecule 3 (JAM3) dual-gene has attracted much attention. Some studies have reported that it is related to the migration and invasion of cervical cancer cells. Although the current related research is not yet perfect, the PAX1/JAM3 dual-gene methylation has great potential in the field of cervical cancer screening and treatment. The combined application of PAX1/JAM3 dual-gene methylation can help optimize the cervical cancer screening strategy and improve the accuracy of clinical triage. This review summarizes the application of PAX1/JAM3 dual-gene methylation in cervical cancer screening and treatment, aiming to provide a theoretical basis for the precise implementation and hierarchical management of cervical cancer screening.

Key words: Cervical intraepithelial neoplasia, Uterine cervical neoplasms, DNA methylation, Paired box gene 1, Junctional adhesion molecule 3

刘倩, 杨帆, 徐冉, 王新立. PAX1/JAM3双基因甲基化在宫颈癌筛查及治疗中的应用[J]. 国际妇产科学杂志, 2025, 52(6): 702-707.

LIU Qian, YANG Fan, XU Ran, WANG Xin-li. Application of PAX1/JAM3 Dual-Gene Methylation in Cervical Cancer Screening and Treatment[J]. Journal of International Obstetrics and Gynecology, 2025, 52(6): 702-707.

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