国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 184-185.

• 论著 • 上一篇    下一篇

卵巢癌中EphrinA3的表达及其意义的分析

鲍留平，仲建新   

  1. 224600 江苏省响水县人民医院妇产科（鲍留平）；南通大学附属医院妇产科（仲建新）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15

EphrinA3 Expression and Significance of Analysis in Ovarian Cancer

BAO Liu-ping，ZHONG Jian-xin   

  1. Department of Obstetrics and Gynecology，Renmin Hospital，Xiangshui County 224600，Jiangsu Province，China（BAO Liu-ping）；Department of Obstetrics and Gynecology，Affiliated Hospital of Nantong University，Nantong 226001，Jiangsu Province，China（ZHONG Jian-xin）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15

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摘要： 目的：检测上皮性卵巢癌组织中EphrinA3的表达水平，初步探讨EphrinA3在卵巢癌发病中的作用。方法：采用免疫组化方法检测上皮性卵巢癌组织中EphrinA3蛋白表达。结果：EphrinA3在卵巢癌组织中阳性表达率为73.3%，高于良性卵巢肿瘤组织（20%）及正常卵巢组织（16.7%）；Ⅲ~Ⅳ期卵巢癌组织中EphrinA3阳性表达率高于Ⅰ~Ⅱ期（83.3% vs. 33.3%，P＜0.01）；在低分化卵巢癌组织中阳性表达率高于中高分化癌组织（80% vs. 40%，P＜0.01）；在淋巴结转移组EphrinA3阳性表达率为88.9%，高于无转移组的50%（P＜0.05）。结论：EphrinA3在上皮性卵巢癌组织中高表达，在不同临床分期及组织学分级中，EphrinA3的表达水平不同。

关键词: 卵巢肿瘤, EphrinA3, 免疫组织化学, 基因, 肿瘤抑制

Abstract: Objective：Detection of EphrinA3 expression level in epithelial ovarian cancer tissue ，preliminary to explore EphrinA3 role in ovarian cancer. Methods：Immunohistochemistry was used to detect the expression of the EphrinA3 protein. Results：Positive expression rate of EphrinA3 in ovarian cancer was 73.3%，significantly higher than that in benign ovarian tumors （20%） and normal ovaries （16.7%）；Ⅲ-Ⅳ ovarian cancer tissue EphrinA3 positive expression rate was significantly higher than Ⅰ-Ⅱ phase（83.3% vs. 33.3%，P＜0.01）；poorly differentiated ovarian carcinoma，the positive expression rate was significantly higher than in well-differentiated ovarian carcinoma （80% vs. 40%，P＜0.01）；EphrinA3 positive expression in lymph node metastasis group was significantly higher than no metastasis group（88.9% vs. 50%，P＜0.05），and regardless of the histopathological type （P＞0.05）. Conclusions：High EphrinA3 expression was in epithelial ovarian cancer，and different expression levels of EphrinA3 were different in different clinical stage and histological grade.

Key words: Ovarian neoplasms, EphrinA3, Immunohistochemistry, Genes, Tumor suppressor