关键词: 外阴上皮内瘤样病变, 外阴肿瘤, 癌, 咪喹莫特, 乳头状瘤病毒科

Abstract: With the vulvar cancer increases in incidence and younger age of onset， vulvar intraepithelial neoplasia lesions are more concerned about as precancerous lesions. This paper describes the vulvar intraepithelial neoplasia lesions of the etiology and classification， clinical features， pathology character， treatment progress and treatment options， recurrence and progression. The therapeutic approach for vulvar intraepithelial neoplasia is variours. The objectives of treatment are not only eliminating lesions to prevent development of invasive vulvar cancer， but also including preservation of normal vulvar function and anatomy. The recurrence ，even after extensive surgical procedures， are common. Surgical excision is currently the standard treatment for vulvar intraepithelial neoplasia， The new treatment modalities， including immunotherapy， focused ultrasound therapy and photodynamic therapy， are easy accepted by patients because of the effectiveness and maintaining relatively normal-appearing and functioning anatomy. Imiquimod is possibly an alternative to currently available methods of treatment. Vaccine against Human Papillomavirus is going to be a dominant modality to prevent vulvar intraepithelial neoplasia.

Key words: Vulva intraepithelial neoplasia, Vulvar neoplasms, Carcinoma, Imiquimod, Papillomaviridae