国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (4): 293-296.

• 综述 • 上一篇    下一篇

磷酸腺苷活化的蛋白激酶与卵巢肿瘤

张翼辛,李 斌   

  1. 200011 上海袁复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-08-15 发布日期:2011-08-15

The Correlation Between AMPK and Ovarian Neoplasms

ZHANG Yi-xin, LI Bin   

  1. Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-08-15 Online:2011-08-15

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摘要： 磷酸腺苷活化的蛋白激酶（AMPK）是体内一种重要的蛋白激酶，广泛分布于全身各组织器官，在调节细胞能量代谢方面发挥着重要作用。AMPK上的苏氨酸172结合位点，以及该位点的磷酸化对其活性的调节发挥着至关重要的作用。对其与肿瘤相关性的深入研究发现，AMPK可被多种途径激活。AMPK及其上游激酶LKB1、钙调蛋白依赖性蛋白激酶的激酶（CaMKK）、转化生长因子β活化的蛋白激酶（TAK1）和丝氨酸/苏氨酸激酶（Akt/PKB）的活化对肿瘤细胞的增殖、生长、侵袭和转移具有复杂的调控作用，有望成为卵巢癌化疗作用中的新靶点。对AMPK在卵巢肿瘤中的研究综述。

关键词: 代谢, 细胞周期, 卵巢肿瘤, 蛋白激酶类, 磷酸腺苷活化的蛋白激酶

Abstract: AMP-activated protein kinase（AMPK）， a significant protein kinase extensive distribution in whole body′s tissues and organs, plays a key role in the regulation of metabolism. Both the Ser172, which is a point on AMPK, and the phosphorylation on it are very important to the regulation of activation of AMPK. The researches of the correlation between AMPK and tumor which gradually go in-depth in recent years—show that AMPK can be activated by many signaling. The activations of AMPK and its upstream kinases, such as LKB1, CaMKK, TAK1 and Akt/PKB, probably have the complex regulatory function in inhibiting the proliferation, invasion and metastasis of tumor cells, which is expected to be the new target in chemotherapy treatments of ovarian cancer. This review will summarize the new discoveries on AMPK in ovarian neoplasms.

Key words: Metabolism, Cell cycle, Ovarian neoplasms, Protein kinases, AMP-activated protein kinase