国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 342-344.

• 论著 • 上一篇    下一篇

晚期先兆流产保胎结局与血白细胞、中性粒细胞、C反应蛋白的关系

任娟娟，于晓辉   

  1. 116033 大连医科大学附属大连市妇幼保健院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 于晓辉

The Relationship between the Result of Protecting Fetus from Late Threatened Abortion and Blood Leukocytes，Neutrophils and the CRP

REN Juan-juan，YU Xiao-hui   

  1. Dalian Medical University Affiliated of Dalian Maternal and Child Health Care Hospital，Dalian 116033，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: YU Xiao-hui

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摘要： 目的：探讨晚期先兆流产保胎结局与血白细胞、中性粒细胞、C反应蛋白（CRP）的关系。方法：选取2012年4月—2013年3月在大连市妇幼保健院因晚期先兆流产住院保胎的患者共227例，所有患者入院时均行血常规、CRP检查。按保胎结局分为保胎成功组与难免流产组，其中保胎成功组181例，保胎成功率79.7%；难免流产组46例，难免流产率20.3%，分析2组血白细胞、中性粒细胞百分比、中性粒细胞绝对值及CRP。结果：保胎成功组与难免流产组比较，血白细胞、中性粒细胞百分比、中性粒细胞绝对值、CRP值差异均有统计学意义（P＜0.05）；保胎成功率与CRP、白细胞和中性粒细胞绝对值呈负相关，难免流产率与中性粒细胞百分比呈正相关（P＜0.05）。通过受试者工作特征曲线分析白细胞、中性粒细胞百分比、中性粒细胞绝对值、CRP对难免流产的预测效果，曲线下面积分别为0.881、0.800、0.800和0.779，敏感度分别为87.0%、76.1%、71.7%和73.9%，特异度分别为75.7%、76.2%、69.6%和81.2%。结论：晚期先兆流产风险与感染有一定相关性；血白细胞、中性粒细胞、CRP对晚期难免流产具有一定预测价值，为临床医生针对性治疗提供了依据。

关键词: 流产, 先兆, 白细胞, 中性白细胞, C反应蛋白质

Abstract: Objective： To explore the relationship between the result of protecting fetus from late threatened abortion and blood leukocytes，neutrophils and the C-reactive protein（CRP）. Methods：A total of 227 patients with late threatened abortion to protect the fetus，from April 2012 to March 2013 in Dalian Obstetrics and Gynecology Hospital，were performed routine blood and CRP examination，subjects were divided into two groups，181 of them protected the fetus successfully with the success rate 79.7%，and 46 cases resulted in inevitable abortion，with the rate 20.3%. And relationship of the blood leukocyte，neutrophil percentage，neutrophils absolute value，and CRP between the two groups were analyzed. Results：Compared with the inevitable abortion group and successfully protected the fetus group，their blood WBC，neutrophil percentage，neutrophils absolute value and CRP were found with statistically difference（P＜0.05）. The successfully protected the fetus group showed an negative correlation with CRP，white blood cell and neutrophil absolute value，while the inevitable abortion and the percentage of neutrophils was positively correlated（P＜0.05）. By ROC curve analysis to predict the inevitable abortion with WBC，neutrophil percentage，neutrophils absolute value and CRP，the area under the curve were calculated to be 0.881，0.800，0.800，0.779，the sensitivity to be 87.0%，76.1%，71.7% and 73.9%，and the specific degree 75.7%，76.2%，69.6% and 81.2% respectively. Conclusions：A certain correlation existed between the risk of late threatened abortion and infection，and blood cells，neutrophils and CRP have moderate predictive value for late inevitable abortion，which provide a certain basis for clinical treatment.

Key words: Abortion, threatened, Leukocytes, Neutrophils, C-reactive protein