国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (5): 558-561.

• 综述 • 上一篇    下一篇

Piwi蛋白与基因的表达调控及其在肿瘤中的作用

张红丽，凌斌，冯定庆   

  1. 230001 合肥，安徽医科大学附属省立医院妇产科（张红丽，凌斌），安徽省分子医学重点实验室（冯定庆）；中日友好医院妇产科（凌斌）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-10-15 发布日期:2014-10-15
  • 通讯作者: 凌斌

Piwi Protein and Gene Expression Regulation and Its Role in Cancer

ZHANG Hong-li，LING Bin，FENG Ding-qing   

  1. Department of Obstetrics and Gynecology（ZHANG Hong-li，LING Bin），Anhui Province Key Laboratory of Molecular Medicine（FENG Ding-qing），Anhui Province Hospital Affiliated to Anhui Medical University，Hefei 230001，China；Department of Obstetrics and Gynecology，China-Japan Friendship Hospital，Beijing 100029，China（LING Bin）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-10-15 Online:2014-10-15
  • Contact: LING Bin

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摘要： Piwi蛋白是Argonaute蛋白家族的一类，正常情况下可表达于不同物种的雄性睾丸组织中，主要与Piwi相关RNA（piRNA）相互作用，导致转座子基因的沉默，保护生殖干细胞基因组的稳定性和完整性，对生殖干细胞的自我更新、配子和胚胎的发育具有重要的作用。另外，在人类多种肿瘤组织如胃癌、乳腺癌、宫颈癌中发现有Piwi蛋白表达，同时在肿瘤干细胞中也有Piwi蛋白的表达，抑制其表达可通过多种不同机制抑制肿瘤细胞的增殖和凋亡，说明Piwi蛋白与肿瘤的发生发展有关。现就Piwi蛋白调控基因表达及其与肿瘤发生发展的关系作一综述。

关键词: 肿瘤, 干细胞, 肿瘤干细胞, Piwi蛋白

Abstract: The Piwi proteins, a class of Argonaute protein family, are predominantly present in different species of the male testes. It can associate with a novel class of small RNAs known as Piwi-interacting RNAs （piRNAs）, lead to transposon gene repression, so that to protect genome integrity and functions of germline stem cell, these plays an important role in self-renewal of germline stem cell, gametogenesis and embryo development. In addition, Piwi proteins was reported to be expressed in various types of human tumor tissue including breast, gastrointestinal and cervical cancer, especially, it is stably expressed in cancer stem cell. Inhibiting its expression can suppress tumor cell proliferation and apoptosis through a variety of different mechanisms, indicating that it might play an important role in tumor initiation and progression. Here is to make a review of the mechanism of Piwi proteins regulate gene expression and its relations with tumorigenesis.

Key words: Neoplasms, Stem cells, Neoplastic stem cells, Piwi proteins