国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (4): 253-256.

• 综述 • 上一篇    下一篇

缝隙连接蛋白43在子宫平滑肌细胞的表达调控

何淑琼，颜建英   

  1. 350300 福州，福建医科大学教学医院福建省妇幼保健院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-08-15 发布日期:2010-08-15

Expression and Regulation of Connexin 43 and Gap Junction in the Myometrial Smooth Muscle Cell

HE Shu-qiong， YAN Jian-ying   

  1. Department of Obstertrics and Gynecology, Fujian Medical University Teaching Hospital Fujian Maternity and Child Health Hospital，Fuzhou 350001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-08-15 Online:2010-08-15

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摘要： 缝隙连接是细胞间的直接通讯方式。缝隙连接蛋白43（CX43）是构成细胞缝隙连接的主要蛋白，在子宫平滑肌呈特异性表达，可调控子宫平滑肌细胞内信号通路，影响子宫收缩的协调性和节律性。就缝隙连接与CX43的关系、CX43在子宫平滑肌细胞内的表达及通过对其磷酸化位点的磷酸化作用调控子宫平滑肌细胞内信号通路等综述。探讨CX43如何调控子宫收缩协调性、同步性和极性，为早产和宫缩乏力性产后出血的预防和治疗提供理论支持。

关键词: 连接蛋白43, 缝隙连接, 子宫肌层, 肌细胞, 平滑肌, 细胞外隙, 细胞间通讯

Abstract: Gap junction plays a significant role in intercellular direct communication. Connexin 43 （CX43），the major protein in the intercellular gap junction, has specific expression in uterine myometrium. It can regulate the signaling pathway of myometrial smooth muscle cell，thereby affect the coordination of uterine contraction. The paper indicates the relationship between CX43 protein and gap junction, the role of CX43 in the expression in myometrial smooth muscle cell and how phosphorylation events regulate the signaling pathways in it， and how CX43 protein affect the coordination and contraction of uterine，then provides the theory support for the prevention of premature birth and postpartum hemorrhage caused by uterine inertia.

Key words: Connexin 43, Gap junction, Myometrium, Myocytes, Smooth muscle, Extracellular space