Abstract: Objective：A 3-year follow-up evaluation of the safety, efficacy and outcome analysis of the second generation of endometrial ablation using the NovaSure system. Methods：A study of 70 women with menorrhagia secondary to abnormal uterine bleeding （AUB） who underwent endometrial ablation using the NovaSure system at hysteroscopic center, Fuxing Hospital, Capital Medical University, from January 2011 to December 2013. General condition of these patients, treatment time, complications, hemoglobin and endometrial thickness before and after the operation and rate of surgical re-interventions were recorded. Results：①Patient: The patient age in this cohort ranged from 28-54 years with a median age of （43.5±5.5） years. 27.1%（19/70） had serious medical complications. The mean sounding length was （9.17±1.12） cm. The time of energy delivery was （122.00±19.73） s, range from 55-179 s. All patients reported small amount of bleeding, less than 10 mL. No complications occurred. ②At 3-year follow-up, 97.1%（68/70） experienced a successful reduction in bleeding, 54.3%（38/70） of patients reported amenorrhea. Two of 70 had additional surgery during the follow-up period. 28.6%（20/70） of patients reported fluid accumulation in the uterine cavity. ③Hemoglobin and endometrial thickness before and after the operation has a very significant difference （P=0.000）, 98.56 g/L vs. 115.27 g/L, 9.2 mm vs. 3.4 mm, respectively. ④Menorrhagia with and without adenomyosis group, amenorhea rate has a very significant difference （χ2=6.860，P=0.013）. Conclusions：Clinical result indicate that the NovaSure system is safe and effective method for treatment of women with menorrhagia. Adenomyosis may be one of factors influencing curative effects.

Key words: Uterine hemorrhage, Endometriosis, Adenomyosis, Endometrial ablation, NovaSure