Abstract: Objective: To investigate the expression of Tn antigen in cervical carcinoma. To explore the role of Tn antigen in the occurrence and development of cervical carcinoma, and to provide a reference for the early diagnosis, treatment of cervical carcinoma. Methods: We screened 102 cervical samples from the Second Hospital of Jilin University from 2013 to 2015, including 66 invasive cervical carcinomas, 22 cervical intraepithelial neoplasia（CIN）, 14 normal cervical squamous epithelia, by immunohistochemistry using biotinylated vicia villosa lectin（VVL）. Results: The Tn antigen was rarely observed in normal squamous epithelium(7.1%）, and was detected in 45.5% of CIN and in 68.8% of invasive squamous carcinoma, and was highly observed in 94.1% of invasive adenocarcinoma. In invasive squamous carcinoma, expression of Tn antigen was closely related to lymph node metastasis（r=0.363，P＜0.05）. In adenocarcinoma, the correlation was shown between Tn expression and depth of invation（r=0.361，P＜0.05）. Conclusions：Tn antigen could be used as a marker for cervical adenocarcinoma, and Tn antigen could indicate the potent risk of lymph-nodes metastasis in squamous carcinoma.