Abstract: Cervical carcinoma is one of the most common cancers of women, which has a higher incidence in developing countries. With the popularization of the screening in cervical carcinoma, the incidence of cervical carcinoma, especially squamous cell carcinoma has declined. However, because human papilloma virus (HPV) infection does not always accompany cervical adenocarcinoma and the lesion is deep into the cervical canal, the existing screening methods are less effective in the diagnosis of cervical adenocarcinoma. Compared with cervical squamous cell carcinoma, the prognosis of cervical adenocarcinoma is poor. Gene methylation is an important part of epigenetic modification, which can change gene structure and inhibit gene expression without changing DNA sequence. The methylation of tumor suppressor gene can make it inactivated and lose its inhibitory effect on tumor, which is closely related to the occurrence and development of tumor. In this paper, the research progress of gene methylation in cervical adenocarcinoma was reviewed in order to provide new ideas for early diagnosis and treatment of cervical adenocarcinoma.

Key words: Uterine cervical neoplasms；, Adenocarcinoma；, DNA methylation；, Genes, tumor suppressor；, Diagnosis；, Therapy