Research Progress on the Role of Long Non-Coding RNA in the Occurrence and Development of Cervical Cancer

doi:10.12280/gjfckx.20200425

Abstract

Abstract:

Cervical cancer is one of the common gynecological malignancies. The etiology of the disease has been clear, mainly the persistent infection of human papillomavirus (HPV). In recent years, with the advent of preventive vaccines and the popularization of screening work, early diagnosis and treatment of cervical cancer have achieved some results. However, its incidence and mortality are still high, which seriously threatens the life and health of women. Actively exploring the early diagnosis and treatment of cervical cancer can further improve the prognosis of patients with cervical cancer. Long non-coding RNA (lncRNA) is a kind of RNA without protein coding function, which participates in many biological processes. lncRNA is abnormally expressed in a variety of malignant tumors and plays a role in carcinogenesis or cancer inhibition. More and more studies have found that lncRNA is closely related to cervical cancer and plays an important role in the occurrence, invasion, metastasis and drug resistance of cervical cancer. To explore the role of lncRNA such as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), HOX antisense intergenic RNA (HOTAIR), antisense non-coding RNA in the INK4 locus (ANRIL), EBIC, CCHE1 in the development of cervical cancer, and to summarize their molecular mechanisms in cervical cancer, so as to provide new ideas for the early diagnosis and targeted therapy of cervical cancer.

Key words: RNA, long noncoding, Uterine cervical neoplasms, Biomarkers, tumor, Carcinogenesis, Molecular targeted therapy

XIN Yu-qi, TIAN Lei, WANG Xiao-hui. Research Progress on the Role of Long Non-Coding RNA in the Occurrence and Development of Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 41-46.

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