Research Progress of Statins in Ovarian Cancer

doi:10.12280/gjfckx.20220624

Abstract

Abstract:

Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) inhibitors that reduce plasma cholesterol level by reducing cholesterol biosynthesis and inducing changes in low-density lipoprotein receptor expression. It is widely used in the treatment of hyperlipidemia and the prevention of cardiovascular and cerebrovascular diseases. In addition, statins may have potential anticancer effects by blocking cell cycle progression, inducing apoptosis, inhibiting angiogenesis, and inhibiting tumor growth and metastasis. Ovarian cancer has a poor prognosis and causes severe economic and psychological burden to patients. Statins exert anti-tumor effects and improve the chemoresistance of ovarian cancer by inhibiting mevalonic acid (MVA) pathway, promoting ferroptosis regulating autophagy and tumor microenvironment (TME). Studies have shown that statins, to some extent, can inhibit ovarian cancer cell proliferation, reduce the risk of ovarian cancer, improve the prognosis, synergize and enhance the anti-tumor effects of chemotherapy drugs, and reduce the recurrence rate. This article reviews the research progress of statins in the prevention and treatment of ovarian cancer, in order to provide help for future clinical practice.

Key words: Ovarian neoplasms, Hydroxymethylglutaryl-CoA reductase inhibitors, Antineoplastic agents, Therapy, Prognosis

LI Yu-lan, XIAO Chen-meng, LIU Xiao, HAN Feng-jiao, YUE Ling, XU Fei-xue. Research Progress of Statins in Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 25-29.

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