Application and Progress of Adipose Derived Mesenchymal Stem Cell Exosomes in Gynecological Diseases

doi:10.12280/gjfckx.20230908

Abstract

Abstract:

With the development of stem cell research, adipose derived mesenchymal stem cell (ADSC) and adipose derived mesenchymal stem cell exosome (ADSC-Exo) have become a hot research topic in the field of gynecology. ADSC, a type of adipose-derived mesenchymal stem cells, has high proliferative capacity and multidirectional differentiation potential like other mesenchymal stem cells. ADSC-Exo can deliver a variety of biologically active molecules, such as microRNAs, proteins, and cytokines through released extracellular vesicles to play a certain regulatory role in the target cells. The application of ADSC-Exo in gynecology has also received increasing attention. Some studies have shown that ADSC-Exo can promote endometrial regeneration and repair, bringing hope to patients with intrauterine adhesion and infertility. In addition, some studies mentioned that ADSC-Exo also has potential in the treatment of chronic endometritis, ovarian insufficiency, polycystic ovary syndrome and gynecological malignancies. This paper reviews the application and advancements of ADSC-Exo in gynecology.

Key words: Mesenchymal stem cells, Exosomes, Genital diseases, female, Therapy, Adipose derived mesenchymal stem cell exosome

SHI Li-juan, YU Xiao-chuan, WANG Hua-li. Application and Progress of Adipose Derived Mesenchymal Stem Cell Exosomes in Gynecological Diseases[J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 274-278.

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