Abstract:

A case of termination by caesarean section in a pregnant patient with hemophilia A was reported. In this study, the patient had hemophilia A caused by an abnormal coagulation factor Ⅷ (FⅧ) gene, and usually characterized by long bleeding time and intermittent bleeding such as bump trauma. Her mother and elder sister are both carriers of the hemophilia gene, and she had once induced labor with fetal hemophilia. During pregnancy, the patient was closely monitored in the obstetric and hematology clinics, and the activity of FⅧ (FⅧ:C), plasma FⅧ inhibitor and coagulation function were regularly rechecked. The patient was hospitalized three days before term，completed those examination and treated with coagulation factor transfusion. The patient was successfully terminated by full-term cesarean section at 37 weeks of gestation, and the indication for surgery is breech presentation. The surgery went smoothly, the intraoperative bleeding was 300 mL as normal. The newborn weighed 2 990 g, the Apgar score of 1 min and 5 min after birth was 10 points, and was sent to the neonatal department for further observation. The patient had no abnormal bleeding after surgery, and was successfully discharged on the 11th day postpartum, the newborn was discharged on the 5th day, the maternal and child have a good outcome.

Key words: Pregnancy, Hemophilia A, Term birth, Therapy, Case reports