Research Progress on Impaired Endometrial Receptivity in Endometriosis

doi:10.12280/gjfckx.20260238

Abstract

Abstract:

Endometriosis (EMs) is one of the common causes of infertility in women of reproductive age, posing a serious threat to female reproductive health. The pathogenesis of EMs-related infertility is complex. Current research indicates that impaired endometrial receptivity is a key factor leading to embryo implantation failure in patients with EMs. The specific mechanisms include: an imbalance in the quantity and proportion of endometrial immune cells secreting pro-inflammatory factors, disrupting the endometrial immune microenvironment; increased estrogen synthesis caused by ectopic lesions, downregulation of progesterone receptor expression leading to progesterone resistance, resulting in an imbalance in estrogen and progesterone signaling pathways and interference with cyclical endometrial changes; and abnormal expression of key receptivity genes and dysregulation at the epigenetic level, affecting the normal decidualization process of endometrial stromal cells. This review summarizes the relationship between the aforementioned mechanisms and impaired endometrial receptivity in EMs, providing a theoretical basis and new research directions for clinically improving endometrial receptivity and pregnancy outcomes in patients with EMs.

Key words: Endometriosis, Embryo implantation, Signal transduction, Epigenomics, Endometrial receptivity

WU Yu, MA Sai-hua, WU Lin-ling, ZHANG Hai-jiao, GAO Ye. Research Progress on Impaired Endometrial Receptivity in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2026, 53(4): 406-411.

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