Abstract: Endometriosis seriously impacts on women′s life，whose etiology is still unknown. Vascular endothelial growth factor（ＶＥＧＦ） may affect the occurrence and development of endometriosis. VEGF gene has at least 30 single nucleotide polymorphisms，of which -460 C/T，+405 G/C （also known as -634 G/C），+936 C/T，-1154 G / A and -2578 A/C are more studied. These sites may impact on the development of endometriosis by influencing production of VEGF. The main gene regulation level of VEGF is in transcription and post-transcription，whose specific regulatory mechanism is not clear , and it can be affected by many factors，such as drugs，in vivo environment and in vitro environment. Research on the influence of VEGF gene polymorphisms and its regulation pathways on endometriosis will help scholars understanding the pathogenesis of endometriosis more so as to provide ideas of new ways to treat endometriosis.

Key words: Endometriosis, Vascular endothelial growth factors, Gene expression, Genes