葡萄胎免疫学研究进展

doi:10.12280/gjfckx.20210617

摘要/Abstract

摘要：

葡萄胎来源的滋养细胞和正常妊娠来源的滋养细胞均起源于胚胎的外胚层,受到父系印迹基因的调控。正常妊娠来源的妊娠早期滋养细胞可通过表达非经典人类白细胞抗原以及诱导免疫细胞的抑制表型等多种机制诱导母胎界面局部免疫耐受,以保护胚胎的正常生长发育。然而,目前对葡萄胎免疫学改变的了解仍有限。近年来研究发现葡萄胎来源的滋养细胞与母胎界面局部免疫细胞相互作用是影响其清宫术后预后的重要因素。葡萄胎患者外周血单个核细胞（peripheral blood mononuclear cell,PBMC）免疫状态与葡萄胎的发生、发展密切相关,其反映了患者免疫系统对葡萄胎持续妊娠作出的适应性改变。为探讨葡萄胎上述免疫学特点,就近年关于葡萄胎母胎界面免疫细胞组成及其PBMC免疫状态相关研究进展进行综述。

关键词: 妊娠滋养细胞疾病, 葡萄胎, 免疫, 免疫,细胞, 疾病恶化, 外周血单个核细胞

Abstract:

The trophoblasts of the hydatidiform mole and those of normal pregnancy were both originated from the ectoderm and were regulated by paternally imprinted genes. Trophoblasts of normal pregnancy during early pregnancy could induce immune tolerance at the maternal-fetal interface by expressing non-classical human leukocyte antigen and inducing immune cell suppression to ensure fetuses′ normal growth and development. However, the current understanding of the immunological changes of the hydatidiform mole was still limited. Recently, studies have revealed that the interaction between trophoblasts of the hydatidiform mole and immune cells of the maternal-fetal interface was a crucial factor that influenced the prognosis after uterine evacuation. The immune response of peripheral blood mononuclear cell (PBMC) in patients with mole was associated with the advance of mole, which reflected the adaptive changes of the patient′s immune system to the continuous pregnancy of mole. In order to explore the above-mentioned immunological characteristics of hydatidiform mole, this paper reviewed the recent research progress on the composition of immune cells at the maternal-fetal interface of hydatidiform mole and the immune status of PBMC.

Key words: Gestational trophoblastic disease, Hydatidiform mole, Immunity, Immunity,cellular, Disease progression, Peripheral blood mononuclear cell

朱国华, 杜美蓉, 鹿欣. 葡萄胎免疫学研究进展[J]. 国际妇产科学杂志, 2022, 49(2): 217-221.

ZHU Guo-hua, DU Mei-rong, LU Xin. Research Progress of Hydatidiform Mole′s Immunology[J]. Journal of International Obstetrics and Gynecology, 2022, 49(2): 217-221.

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