类器官在子宫内膜及其相关疾病研究中的应用

doi:10.12280/gjfckx.20230197

摘要/Abstract

摘要：

类器官作为一种新兴的三维细胞模型，能够保留体内原始组织的组织学、生理学及遗传学特征，且具备培养时间短、增殖效率高等优势，已广泛应用于生命科学领域。近年来，类器官在子宫内膜相关研究中开展应用，突破了传统细胞和动物模型的局限，可更好地模拟子宫内膜周期性生理变化和胚胎着床特征，并在子宫内膜异位症、子宫内膜癌和不孕症等子宫内膜相关疾病的疾病建模、精准医学、药物筛选及研发方面展现出巨大潜力。综述类器官在子宫内膜基础及相关疾病转化研究中的应用进展。

关键词: 类器官, 子宫内膜, 子宫内膜异位症, 子宫内膜肿瘤, 不育, 女（雌）性

Abstract:

Organoids are three-dimensional cellular models cultured in vitro that retain the histological, physiological, and genetic characteristics of original tissues in vivo. They have the advantages of short culture time and high proliferative efficiency. In recent years, organoids have been widely applied in the field of life sciences, particularly in the endometrial research. By overcoming the limitations of conventional cell and animal models, organoids provide a more accurate simulation of the cyclic physiological changes of the endometrium and the characteristics of embryo implantation. Additionally, they show significant potential in disease modeling, precision medicine, drug screening for endometrium-related diseases such as endometriosis, endometrial tumors, and infertility. This review summarizes the progress in the application of organoids in translational research of basic endometrial and related diseases.

Key words: Organoids, Endometrium, Endometriosis, Endometrial neoplasms, Infertility, female

张小蕾, 邓丹妮, 高燕, 张惠民. 类器官在子宫内膜及其相关疾病研究中的应用[J]. 国际妇产科学杂志, 2023, 50(4): 446-449.

ZHANG Xiao-lei, DENG Dan-ni, GAO Yan, ZHANG Hui-min. Application of Organoids in Research of Endometrium and Endometrium-Related Diseases[J]. Journal of International Obstetrics and Gynecology, 2023, 50(4): 446-449.

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