国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (2): 115-119.

• 综述 • 上一篇    下一篇

妇科肿瘤与炎症

欧阳婧 万 菁 万小平   

  1. 200030 上海交通大学医学院附属国际和平妇幼保健 院(欧阳婧,万小平);上海交通大学附属第一人民医院妇产科(万菁)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 万小平

Gynecological Malignancies and Inflammation

OU-YANG Jing, WAN Jing, WAN Xiao-ping   

  1. Shanghai Jiaotong University Affilated International Peace Maternity and Child Health Hospital , Shanghai 200030, China(OU-YANG Jin, WAN Xiao-ping);Department of Gynaecology and Obstetric,the First Affiliated Renmin Hosiptal of Shanghai Jiaotong University,Shanghai 200080, China(WAN Jing)
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-04-15 Online:2011-04-15
  • Contact: WAN Xiao-ping

摘要: 证据表明,炎症在恶性肿瘤的发生、发展等方面发挥着重要作用,同时固有免疫的某些信号分子,如选择素、趋化因子及其受体能促进肿瘤细胞侵袭、迁移和转移,从而促进肿瘤转移。肿瘤细胞、周围正常的宿主基质细胞和浸润的炎性细胞共同组成一个整体——肿瘤微环境,这一微环境包含各类炎性细胞和炎性分子,是肿瘤细胞持续增殖的基础。研究炎症与妇科肿瘤的关系有助于了解妇科肿瘤发病机制,为妇科肿瘤治疗提供新策略。

关键词: 炎症, 生殖器肿瘤, 女(雌)性, 宫颈肿瘤, 子宫内膜肿瘤, 卵巢肿瘤

Abstract: There are growing evidences showing that inflammation plays an important role in carcinogenesis, development and metastasis and other aspects. In addition, some signaling molecules involved in innate immunity such as selectins, chemokines and their receptors can promote tumor cell invasion, migration and metastasis. Tumor cells, the surrounding normal host stromal cells and infiltrating inflammatory cells, together constitute tumor micro-environment,the micro-environment that contains various types of inflammatory cells and molecules is the basis for the continued proliferation of tumor cells. Research on the relationship between inflammation and gynecologic malignancies will not only help to understand the pathogenesis of gynecologic malignancies, but also provide a new strategy for the treatment of gynecologic malignancies.

Key words: Inflammation, Genital neoplasms, female, Uterine cervical neoplasms, Endometrial neoplasms, Ovarian neoplasms