国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 271-275.

• 综述 • 上一篇    下一篇

sFlt-1及PLGF与子痫前期发病的关系

何淑琼,颜建英   

  1. 350001 福州,福建医科大学教学医院,福建省妇幼保健院妇产科(现就读福建医科大学同等学历研究生)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 颜建英

sFlt-1，PLGF and Their Role in Pathogensis and Prediction of Preeclampsia

HE Shu-qiong， YAN Jian-ying   

  1. Department of Obstetrics and Gynecology, Fujian Provincial Maternity and Child Health Hospital，Fu jian Medical University Teaching Hospital，Fuzhou 350001，China（now studying at Fujian Medical University）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: YAN Jian-ying

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摘要： 可溶性血管内皮生长因子受体1（sFlt-1）与Flt-1均属于血管内皮生长因子受体（VEGFR），其与Flt-1竞争结合VEGF，完全阻断VEGF的生物学活性，引起血管生成障碍并影响血管壁的完整性和通透性。胎盘生长因子（PLGF）是VEGF家族成员之一，PLGF与Flt-1受体结合时，发挥促血管生成和促绒毛滋养细胞增殖、浸润的效应，而这些生物学功能均可被sFlt-1阻断，且sFlt-1对PLGF具有强效的拮抗作用，调节PLGF的功能。在子痫前期妊娠妇女血清中sFlt-1的水平升高，早于疾病的发生。子痫前期患者血浆中PLGF的水平降低。sFlt-1在子痫前期发生发展过程中的作用可能与磷酯酰肌醇3激酶/蛋白激酶B（PI3K/Akt）信号转导通路有关。联合测定妊娠妇女血PLGF、sFlt-1预测子痫前期的发生，有较高的敏感度及特异度。

关键词: 血管内皮生长因子受体1, 胎盘, 先兆子痫, 胎盘微血管密度, 信号转导

Abstract: sFlt-1 and Flt-1 belong to the vascular endothelial growth factor receptor（VEGFR），sFlt-1 competition binding with VEGF，completely abolished the biological activity of VEGF， inhabited angiogenesis and affected the vascular wall barrier integrity and permeability. Placental growth factor（PLGF） is a member of the VEGF family，PLGF binds with Flt-1 receptor，and promotes angiogenesis and trophoblast proliferation. These biological functions can be blocked by sFlt-1 receptor，sFlt-1 plays an important role in regulate PLGF. sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease. Levels of PLGF are lower in preeclampsia serum compare to normal. sFlt-1 plays a major role in the pathogenesis of preeclampsia， it is unclear how hypoxia regulates placental sFlt-1 expression，maybe the PI3K-Akt pathway plays an important role in regulating the expression of sFlt-1. sFlt-1 and PLGF might be used as markers for predicting preeclampisa.

Key words: Vascular endothelial growth factor receptor-1, Placenta, Pre-eclampsia, Microvessel density, Signal transduction