国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (4): 356-359.

• 综述 • 上一篇    下一篇

卵巢癌相关代谢组学研究进展

周颖群, 狄 文   

  1. 200127 上海交通大学医学院附属仁济医院妇产科,上海市教育委员会重点学科,上海市妇科肿瘤重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 狄 文

Advances on Ovarian Cancer Related Metabolomics

ZHOU Ying-qun，DI Wen   

  1. Department of Obstetrics and Gynecology，Renji Hospital，School of Medicine，Shanghai Jiao Tong University；Shanghai Key Laboratory of Gynecologic Oncology；Focus Construction Subject of Shanghai Education Department，Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-08-15 Online:2012-08-15
  • Contact: DI Wen

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摘要： 代谢组学是一种新的组学研究手段，其使用分析化学的检测方法和生物信息学的统计策略对生物系统（细胞、组织、生命体）中所有小分子代谢产物进行分析，任何生理或病理改变都可由代谢表型所反映，卵巢癌发生发展中表现出的代谢变化规律必然可由代谢组学研究测定，以获得系统性、整体性、动态性的信息，为卵巢癌的早期诊断、合理治疗提供理论依据。就代谢组学的概念、研究方法及其在卵巢癌中的应用做一综述。

关键词: 代谢, 卵巢肿瘤, 磁共振波谱学, 气相色谱-质谱法, 生物医学研究

Abstract: Metabolomics is a new “omics” techniques which uses analytical chemistry detection methods and bioinformatics strategy to study the global metabolites in biological systems （cells， tissues， living organisms）. Any physiological or pathological changes can be revealed by the metabolic phenotype， the metabolic changes demonstrated in the development of ovarian cancer must be measured by metabolomics. The systematic，holistic，dynamic information for ovarian cancer will be obtained， which can provide a theoretical basis for early diagnosis and proper treatment. There is a review for the concept of metabolomics， their research methods and applications on ovarian cancer.

Key words: Metabolism, Ovarian neoplasms, Magnetic resonance spectroscopy, Gas chromatography-mass spectrometry, Biomedical research