国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 255-257.

• 综述 • 上一篇    下一篇

叉头状/翼状螺旋转录因子3与妇科恶性肿瘤相关性研究进展

马宁耶，张淑兰   

  1. 110004 沈阳，中国医科大学盛京医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 张淑兰

Research Progress of Correlation between Forkhead Transcription 3 and Malignant Gynecology Tumor

MA Ning-ye，ZHANG Shu-lan   

  1. Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15
  • Contact: ZHANG Shu-lan

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摘要： 叉头状/翼状螺旋转录因子3（forkhead or winged helix transcription，FOXP3）是叉头家族成员之一，特异地表达于CD4+CD25+Treg（regulatory T cell，调节性T细胞）中，决定 CD4+CD25+Treg的发育和功能的发挥，而Treg的表达可以阻碍机体对癌症的免疫监视，抑制自体肿瘤细胞抗原有效的免疫反应。这使得FOXP3成为恶性肿瘤免疫机制的研究热点。在卵巢癌中，FOXP3的高表达提示低生存率，并不受其他因素影响。在宫颈癌中，无论是血液、宫颈黏膜以及宫颈活检组织中都可以检测到FOXP3的高表达。

关键词: FOXP3, 自身免疫, T淋巴细胞, 调节性, 卵巢肿瘤, 宫颈肿瘤

Abstract: FOXP3 is a member of winged helix transcription family，specific expressed in CD4+CD25+Treg（regulatory T cell），which decide the development and function of Treg. The expression of Treg can prevent the immune surveillance of cancer，inhibits the effective immune reaction of tumor antigen，which makes FOXP3 become the study hotpot of tumor immune. In ovarian cancer， research says the high expression of FOXP3 is an independent prognostic factor of survival rate；In breast cancer，FOXP3 is a significant mark of tumor progression and metastasis，and it is the transcription inhibitor of breast cancer gene SKP2;While in cervical cancer，no matter in blood，cervical mucosa and cervical biopsy，it can all be tested highly expressed.

Key words: FOXP3, Autoimmunity, T-Lymphocytes, regulatory, Ovarian neoplasms, Uterine cervical neoplasms