国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 251-254.

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人附睾分泌蛋白4在妇科肿瘤中的研究进展


禹 夜，林仲秋   

  1. 510120 广州，中山大学孙逸仙纪念医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15

HE4 as A Biomarker for Gynecology Oncology

YU Ye，LIN Zhong-qiu   

  1. Department of Obstetrics and Gynecology，SUN Yat-sen Memorial Hospital，SUN Yat-sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15

PDF (PC)

5047

被引次数

8

摘要： 人附睾分泌蛋白4（HE4）是近年发现的新妇科肿瘤标记物，其在正常子宫内膜及卵巢中低表达的特性使其在妇科恶性肿瘤中的诊断具有独特的价值。研究表明，HE4在卵巢癌的早期诊断、鉴别诊断等方面已显示出一定的优越性，其在评价卵巢癌的预后以及早期监测复发上可能优于糖类抗原125（CA125）。HE4对子宫内膜癌的诊断也有研究报道。HE4作为一种新肿瘤标记物与CA125联用，对卵巢癌、子宫内膜癌等妇科肿瘤的诊断、鉴别诊断、风险预测均有很好的临床价值。HE4在子宫肌瘤等良性妇科疾病的诊断及鉴别诊断中也具有一定的临床价值。

关键词: 人附睾分泌蛋白4, 肿瘤标记, 生物学, 卵巢肿瘤, 子宫内膜肿瘤, 诊断, 预后

Abstract: Human sapiens epididymis specific protein 4（HE4） is a recently discovered tumor marker. It shows promising prospective in early and differential diagnosis of ovarian cancer. HE4 compared to CA125，potentially is a better marker for prognosis of OC and could be an important indicator of the recurrence of the disease. There are aslo some researches about the value of HE4 in endometrium carcinoma. HE4 as a new tumor biomarker has greater potential than CA125 in the diagnosis， differential diagnosis and prognosis of OC and endometrium carcinoma. HE4 could be in value for diagnosis of begin diseases such as uterus myoma or endometriosis.

Key words: Human sapiens epididymis specific protein 4, Tumor markers, biological, Ovarian neoplasms, Endometrial neoplasms, Diagnosis