国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 414-418.

• 综述 • 上一篇    下一篇

子宫内膜癌化疗进展

郝曼，金平   

  1. 730000 兰州大学第一医院妇产科（郝曼）；南方医科大学附属深圳妇幼保健院（金平）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15

Advances in the Chemotherapy of Endometrial Carcinoma

HAO Man，JIN Ping   

  1. Department of Obstetrics and Gynecology，the First Hospital of Lanzhou University，Lanzhou 730000，China（HAO Man）；Shenzhen Maternal and Child Health Hospital，Southern Medical University，Shenzhen 510515，China（JIN Ping）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15

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摘要： 子宫内膜癌（endometrial carcinoma）是女性生殖系统最常见的恶性肿瘤之一。传统治疗以手术为主，辅以放疗、激素治疗和化疗。以往化疗多用于晚期及复发子宫内膜癌患者的治疗，最近研究认为，对早期高危子宫内膜癌辅助化疗或化疗联合放疗可降低局部复发和远处转移病率。化疗的适应证、药物的选择及方案的制定都影响化疗疗效。新兴分子靶向治疗药物较传统化疗药物毒副作用弱，目前临床应用研究较少，价格昂贵，疗效不确切，临床尚未作为常规治疗方案。

关键词: 子宫内膜肿瘤, 癌, 抗肿瘤联合化疗方案, 化学疗法, 肿瘤, 局部灌注, 分子靶向治疗

Abstract: Endometrial carcinoma is the most common malignancy of the female genital tract. The traditional treatment of endometrial cancer is surgical excision supplemented by radiotherapy，chemotherapy and hormone therapy. Chemotherapy were used for the treatment of advanced and recurrent cancer patients，the recent studies concluded that adjuvant chemotherapy or chemotherapy combined with radiotherapy can reduce the rate of local recurrence and distant metastasis disease for the early high-risk endometrial cancer. Indications of chemotherapy，drug selection and chemotherapy regimens could affected the efficacy of chemotherapy. The side-effects of molecular targeted therapeutic drugs are weaker than chemotherapy drugs，too expensive of the clinical application and efficacy are not plausible，is not recommended as routine treatment.

Key words: Endometrial neoplasms, Carcinoma, Antineoplastic combined chemotherapy protocols, Chemotherapy, cancer, regional perfusion