国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (2): 136-140.

• 综述 • 上一篇    下一篇

微小RNA与卵巢癌研究进展

李明，姜桦   

  1. 200011 上海，复旦大学附属妇产科医院妇科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-15 发布日期:2015-04-15
  • 通讯作者: 姜桦

MicroRNA and Its Role in Ovarian Cancer

LI Ming，JIANG Hua   

  1. Department of Gynecology，Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-15 Online:2015-04-15
  • Contact: JIANG Hua

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摘要： 微小RNA（microRNA，miRNA）是一组存在于真核生物中的长度约21～23个核苷酸的内源性非编码小分子RNA，参与基因转录后水平的调控，在细胞增殖、分化和凋亡中起着非常重要的作用。越来越多的研究表明，miRNA表达水平的改变与多种人类恶性肿瘤的发病和进展有关，如结直肠癌、宫颈癌、卵巢癌等。miRNA 在卵巢癌中异常表达，与其发生、发展、转移、耐药和预后密切相关，有望成为卵巢癌的早期诊断和预后的标记物，并为化疗耐药分析和个性化治疗提供新的临床思路。现就目前研究最多的miR-200家族，let-7家族及miR-199a在卵巢癌中的作用进行综述。

关键词: 微RNAs, 卵巢肿瘤, 癌, 肿瘤转移, 抗药性, 肿瘤, 预后

Abstract: MicroRNA（miRNA） is a type of small evolutionarily conserved non-coding RNAs of 21-23 nucleotides in length that act as post-transcriptional regulators which involves in fundamental cell processes，such as，differentiation，proliferation and death. Recently，it has become clear that alterations in the expression of miRNAs contribute to the pathogenesis and progression of several human malignancies，such as colorectal cancer, cervical cancer, ovarian cancer, and so on. MiRNAs dysregulated expression plays an important role in ovarian cancer pathogenesis，metastasis， resistance and prognosis. They might be used as a noninvasive diagnostic and prognostic biomarker in ovarian cancer，and provide a new clinical thought for the analysis of chemotherapy drug resistance and individualized therapy. This article reviews the functions of miR-200 families,let-7 families and miR-119a, which are frequently dysregulated in ovarian cancer.

Key words: MicroRNAs, Ovarian neoplasms, Carcinoma, Neoplasm metastasis, Drug resistance, neoplasm