国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (2): 154-157.

• 综述 • 上一篇    下一篇

自噬在宫颈癌中的研究进展

赵洪萍,万安,周颖,赵卫东   

  1. 230001 合肥,安徽医科大学附属省立医院妇产科(赵洪萍,万安,周颖,赵卫东);安徽省肿瘤医院妇瘤科(赵卫东)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-15 发布日期:2015-04-15
  • 通讯作者: 赵卫东

The Progress of Autophagy Involved in Cervical Cancer

ZHAO Hong-ping,WAN An,ZHOU Ying,ZHAO Wei-dong   

  1. Department of Obstetrics and Gynecology,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,China(ZHAO Hong-ping,WAN An,ZHOU Ying,ZHAO Wei-dong);Department of Gynecologic Tumor,Anhui Cancer Hospital,Hefei 230000,China(ZHAO Wei-dong)
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-15 Online:2015-04-15
  • Contact: ZHAO Wei-dong

摘要: 越来越多的研究发现机体细胞自噬活性变化对肿瘤的发生发展及对抗肿瘤药物的药效影响具有双重作用。宫颈上皮细胞自噬活性变化对宫颈癌发生发展的影响尚无定论,此外有关自噬与宫颈癌化疗药物作用关系的研究较少。综述自噬影响宫颈癌发生发展的最新研究报道,以及自噬与宫颈癌化疗药的研究,进一步了解自噬在宫颈癌发生发展以及治疗中发挥的作用,为宫颈癌治疗的新途径提供参考方向。

关键词: 自噬, 肿瘤, 宫颈肿瘤, 治疗

Abstract: An increasing number of studies show that the change of autophagy level in normal cell have a dual role in influencing the development of tumor and the efficacy of antitumor drugs. Cervical epithelial cell autophagy activity changing impact on the occurrence and development of cervical cancer is uncertain, and the relationship between autophagy and cervical cancer chemotherapy drug research is less autophagy activity in cervical epithelial cell impacting on the occurrence and development of cervical cancer remains to be determined. In addition, there were a few researches report the relationship between autophagy and the effect of chemotherapy drugs. Reviewing the latest research reports about the effect on autophagy occurrence and development of cervical cancer and the related research of the interaction relationship between autophagy and cervical cancer chemotherapy medicine, to further understand autophagy plays an important role in the development and treatment of cervical cancer, which provide a reference direction for the new therapy of cervical cancer.

Key words: Autophagy, Neoplasms, Uterine cervical neoplasms, Therapy