Abstract: Pre-eclampsia is a disorder specific to human pregnancy, which is one of the main reasons for the death of pregnant women and newborns, but the pathogenesis is still unclear. MicroRNAs（ｍｉＲＮＡｓ） are a class of non-coding small RNAs, expressed in a tissue-specific, developmental stage-specific and disease-specific manner. They are 21-25 nucleotides in length and regulate gene expression at post-transcriptional level. MicroRNAs play important roles in maintaining the normal development of the placenta, so the aberrant miRNAs expression often leads to poor placental development, resulting in the occurrence of pregnancy complications. Several miRNAs are differentially expressed in the placental tissue and serum of pregnant women, who later developed into pre-eclampsia and the target genes of these miRNAs are directly involved in the development of pre-eclampsia. It has been a hot topic to explore the pathogenesis of pre-eclampsia from the perspective of miRNAs. MicroRNAs are expected to be prediction and monitoring biomarkers and therapeutic targets for pre-eclampsia. Here, we summarized the research progress on miRNAs expressed in placenta, especially pre-eclampsia related miRNAs and their target genes.