Abstract: Pre-eclampsia is a serious complication of pregnancy. There is no effective treatment in addition to early delivery. The etiology and pathogenesis of pre-eclampsia is still unclear. Endothelial dysfunction is a characteristic of preeclampsia. Endothelial progenitor cells（EPCs） are stem cells which have the potential of differentiation into vascular endothelial cells. EPCs are mobilized, and then migrated to the injury position to repair the damaged vascular endothelium when endothelial cells were damaged. But the damaged vascular endothelium of pre-eclampsic patient is not restored in time. So we speculate that the number or function of EPCs in pre-eclampsic patient is abnormal. Meanwhile EPCs transplantation may be a new method for the treatment of pre-eclampsia. This paper detailedly explained the relationship between EPCs and pre-eclampsia, summarized the regulation of endothelial progenitor cells, and discussed the possibility of EPCs transplantation for the treatment of pre-eclampsia, so we could find new methods of prevention and treatment of pre-eclampsia.