国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (4): 424-427.

• 综述 • 上一篇    下一篇

微小RNAs在宫颈癌中的异常表达分析

屈建花，曹文君，苗聪秀   

  1. 046000 长治医学院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-08-15 发布日期:2016-08-15

The Analysis of Dysregulated miRNAs Involved in Cervical Cancer

QU Jian-hua, CAO Wen-jun, MIAO Cong-xiu   

  1. Changzhi Medical College, Changzhi 046000, Shanxi Province, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-08-15 Online:2016-08-15

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被引次数

1

摘要： 微小RNAs（microRNAs，miRNAs）是现今肿瘤学研究的热点，与包括宫颈癌在内的多种恶性肿瘤的发生、发展、侵袭、转移密切有关，有关miRNAs与宫颈癌关系的研究日益增多。研究发现，有些机制能引起miRNAs异常表达，且异常表达的miRNAs通过影响重要的调节基因促进宫颈癌的发生，在宫颈肿瘤的恶性转化过程中有重要作用。本文就宫颈癌中miRNAs异常表达的可能机制及其在宫颈癌不同生物学阶段的作用进行综述。

Abstract: MicroRNAs(miRNAs) have become the center of interest in oncology and are closely associated with a variety of tumors including the occurrence, development, invasion and metastasis of cervical cancer. Great concern has been raised regarding the correlation between cervical cancer and miRNAs. Studies demonstrated that some mechanisms could cause aberrant expressions of miRNAs. MiRNAs regulate gene expression by influencing important regulatory genes and thus are responsible for causing cervical cancer which plays a key role in malignant transformation of cervical cancer. In this paper, the pathogenesis of miRNAs dysregulation in different stages of cervical cancer are reviewed.