Abstract: Objective: To compare the efficacy and safety of Mifepristone combined with Misoprostol on abortion of scar uterine pregnancies with different characteristics in mid-term. Methods: A retrospective analysis of medical records of 102 patients with scar uterine pregnancies during June 2012 to May 2015 in our hospital, and Student′s t and chi-square test were used to compare the differences of contractions launch time, the discharge time of the gestational sac, vaginal bleeding, miscarriage and degree-related adverse reactions among the patients with different age （＜35 years vs. ≥35 years）, history of cesarean section （＜1 year vs. 1-2 years vs. ＞2 years） and uterine surgery healing abortion （uniform continuous vs. non-uniform continuous, or weak area vs. no weak area）. Results: The discharge time of fetus and its appendages in patients with no weak areas of uterine scar was shorter than that had weak areas of uterine scar （t=-2.57, P=0.01）, and the distribution of the degrees of abortion was also significant difference between the patients with weak area and without weak area （χ2=11.92, P＜0.01）; the total incidence of adverse effects in patients with non-uniform continuous occurrence of uterine healing was significantly higher than that with uterine healing uniform continuity （χ2=6.32, P=0.01）. Conclusions: Mifepristone combined with Misoprostol was efficient for abortion of scar uterine pregnancies in mid-term that effected by the recovery of the uterus, and patients with weak area in uterine scar and non-uniform continuous occurrence of uterine healing should be further treated and guardianship.