国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (4): 476-480.

• 论著 • 上一篇    

FcRL3（-169T/C）和FOXP3（-2383T/C）基因多态性与子宫内膜异位症的发病风险

卢宇璇，毛耀南，周红梅，魏润新   

  1. 225300  江苏省泰州市，泰州市人民医院药学部
  • 收稿日期:2017-03-24 修回日期:2017-05-25 出版日期:2017-08-15 发布日期:2017-08-15
  • 通讯作者: 魏润新，E-mail: weirunxin1965@sina.com E-mail:luyuxuan4390@sina.com

Genetic Polymorphisms of FcRL3 （-169T/C） and FOXP3 （-2398T/C）with the Risk of Endometriosis

LU Yu-xuan, MAO Yao-nan, ZHOU Hong-mei, WEI Run-xin   

  1. Department of Pharmacy, The People′s Hospital of Taizhou, Taizhou  225300, Jiangsu Province, China
  • Received:2017-03-24 Revised:2017-05-25 Published:2017-08-15 Online:2017-08-15
  • Contact: WEI Run-xin, E-mail: weirunxin1965@sina.com E-mail:luyuxuan4390@sina.com

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摘要： 目的：探讨Fc受体样3（FcRL3）（-169T/C）和叉头样转录因子3（FOXP3）（-2383T/C）基因多态性与子宫内膜异位症（EMs）易感性的关系。方法：检索中国知网、万方、中国生物医学文献数据库（CBM）、Pubmed、Embase等中、英文数据库中发表的关于FcRL3（-169T/C）和FOXP3（-2383T/C）基因多态性与EMs 易感性的文献。对文献进行质量评价、筛选和提取相关病例对照研究资料，使用R软件进行Meta分析，计算合并的比数比（OR）及其95%可信区间（CI）。结果：共纳入文献7篇（其中FcRL3相关文献5篇，累计病例组883例，对照组1 241例；FOXP3相关文献3篇，累计病例组679例，对照组690例）。FcRL3 与FOXP3在等位基因对比模型（T vs. C）中，FcRL3：OR=2.40，95%CI：1.77～3.27，Z=5.57，P＜0.000 1；FOXP3：OR=5.95，95%CI：5.05～7.01，Z=21.40，P＜0.000 1。而在其余分析模型中：杂合子模型（TC vs. CC）（FcRL3：OR=1.23，95%CI：0.80～1.88，Z=0.93，P=0.352；FOXP3：OR=1.75，95%CI：0.80～3.83，Z=1.39，P=0.165）；纯合子模型（TT vs. CC）（FcRL3：OR=1.27，95%CI：0.54～2.97，Z=0.99，P=0.323；FOXP3：OR=0.69，95%CI：0.11～4.33，Z=-0.40，P=0.69）；隐性基因对比模型（TT vs. TC+CC）（FcRL3：OR=1.25，95%CI：0.72～2.14，Z=0.79，P=0.427；FOXP3：OR=1.40，95%CI：0.66～2.95，Z=0.88，P=0.380）以及显性基因对比模型（TT+TC vs. CC）（FcRL3：OR=0.90，95%CI：0.50～1.64，Z=-0.34，P=0.737；FOXP3：OR=1.65，95%CI：0.99～2.73，Z=1.94，P=0.053）。结论：FcRL3（-169T/C）和FOXP3 （-2383T/C）基因多态性可增加EMs的发病风险。
   

关键词: Fc受体样3, 叉头样转录因子3, 子宫内膜异位症, 多态现象, 遗传, Meta分析

Abstract: Objective: In this study, a meta-analysis was performed to clarify the relationship between the genetic polymorphisms of Fc Receptor Like-3 (FcRL3) (-169T/C) and Forkhead box P3 (FOXP3) (-2383T/C) and the risk of endometriosis (EMs).  Methods: Published literatures from PubMed, Embase, CNKI, WanFang, CBM databases were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model according to the heterogeneity. Results: Five studies with 883 cases and 1 241 controls for FcRL3 gene polymorphism and three studies with 679 cases and 690 controls for FOXP3 gene polymorphism were included in the final meta-analysis. The polymorphisms of FcRL3 and FOXP3 was associated with EMs risk in allele model (FcRL3: OR=2.40, 95%CI: 1.77-3.27, Z=5.57, P＜0.000 1; FOXP3: OR=5.95, 95%CI: 5.05-7.01, Z=21.40, P＜0.000 1). And in other models: heterozygote model (TC vs. CC) (FcRL3: OR=1.23, 95%CI: 0.80-1.88, Z=0.93, P=0.352; FOXP3: OR=1.75, 95%CI: 0.80-3.83, Z=1.39, P=0.165); homozygote model (TT vs. CC) (FcRL3: OR=1.27, 95%CI: 0.54-2.97, Z=0.99, P=0.323; FOXP3: OR=0.69, 95%CI: 0.11-4.33, Z=-0.40, P=0.69); Recessive model (TT vs. TC+CC) (FcRL3: OR=1.25, 95%CI: 0.72-2.14, Z=0.79, P=0.427; FOXP3: OR=1.40, 95%CI: 0.66-2.95, Z=0.88, P=0.380); Dominant model (TT+TC vs. CC) (FcRL3: OR=0.90, 95%CI: 0.50-1.64, Z=-0.34, P=0.737; FOXP3: OR=1.65, 95%CI: 0.99-2.73, Z=1.94, P=0.053). Conclusions: Our analysis showed that the polymorphisms of FcRL3(-169T/C) and FOXP3(-2383T/C) were risk factors for EMs.

Key words: FcRL3, FOXP3, Endometriosis, Polymorphism, genetic, Meta-analysis