国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (2): 199-202.

• 论著 • 上一篇    下一篇

益生菌补充对多囊卵巢综合征患者血糖和血脂的影响

陈烨，朱明慧，王婵妮   

  1. 510000  广州市番禺中心医院妇产科
  • 收稿日期:2017-12-11 修回日期:2018-03-12 出版日期:2018-04-15 发布日期:2018-04-15

Effect of Probiotic Supplementation on Blood Sugar and Lipids in Patients with Polycystic Ovary Syndrome

CHEN Ye，ZHU Ming-hui，WANG Chan-ni   

  1. Department of Obstetrics and Gynecology，Guangzhou Panyu Central Hospital，Guangzhou 510000，China
  • Received:2017-12-11 Revised:2018-03-12 Published:2018-04-15 Online:2018-04-15

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摘要： 目的：探讨益生菌补充对多囊卵巢综合征（PCOS）患者血糖和血脂的影响。方法：选取2015年3月—2016年1月于广州市番禺中心医院就诊的60例PCOS患者为研究对象，采用随机数字表法将其分为观察组和对照组，每组各30例。对照组给予常规二甲双胍药物治疗，观察组除给予常规治疗外，加用双歧杆菌三联活菌散。检测2组患者血清标本中空腹血糖（FBS）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）、极低密度脂蛋白胆固醇（VLDL-c）、空腹血清胰岛素（FSI）、黄体生成激素（LH）、卵泡刺激素（FSH）、泌乳素（PRL）、孕酮（P）、雌二醇（E2）和睾酮（T）水平，并计算胰岛素抵抗指数（HOMA-IR）。结果：治疗后观察组患者血清FBS、FSI、HOMA-IR、TG和VLDL水平均显著低于对照组（P＜0.05）；观察组治疗后血清LH和T水平低于治疗前（P＜0.05）。观察组体质量和体质量指数（BMI）较对照组有所下降（P＜0.05）。结论：PCOS患者补充益生菌，其血糖、血脂和体质量指标有所改善，对PCOS及其合并症的发展有一定的缓解作用。

关键词: 有益菌种, 多囊卵巢综合征, 血糖, 血脂异常, 代谢疾病

Abstract: Objective：To investigate probiotic supplementation on blood sugar and lipids in patients with polycystic ovary syndrome. Methods：A total of 60 PCOS patients visited our hospital from March 2015 to January 2016 were divided into observed group (probiotic supplementation) and control group (metformin), each group of 30 cases. Serum levels of Fasting blood sugar (FBS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting serum insulin (FSI), luteotropic hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), progesterone (P), estradiol (E2), testosterone (T) was detected in this study; HOMA-IR were calculated in all patients. Results：Serum FBS, FSI, HOMA-IR, TG and VLDL leves in observed group were significantly decreased compared with control group after treatment (P＜0.05). After treatment, serum LH and T levels in observed group were lower than those before treatment (P＜0.05). In addition, probiotic supplementation in PCOS patients resulted in a significant reduction in weight and BMI compared with those patients without treatment. Conclusions：PCOS patients with probiotic supplementation have favourable effects on blood sugar, blood lipids and weight loss, which could alleviate PCOS and its associated complications development.

Key words: Probiotics, Polycystic ovary syndrome, Blood glucose, Dyslipidemias, Metabolic diseases