关键词: 卵巢肿瘤, 肿瘤转移, 放射疗法, 化学疗法, 辅助, 综合疗法, 基因, BRCA1, 脑转移

Abstract: We described the clinical dates of 2 cases of patients with brain metastases of ovarian cancer of 443 cases of patients with ovarian cancer in detail, including general data of the patients, treatment before and after the diganosis of brain metastases of ovarian cancer, the survival time after brain metastasis of ovarian cancer and so on. We found that the incidence of brain metastases of ovarian cancer is 0.5% in this hospital and the one from the literature is 0.29%-12%. Age and treatment are the most important factors affecting the prognosis. In this study one patient has survived 30 months after treated with multimode comprehensive therapy when diagnosed of brain metastasis of ovarian cancer. The interval time of the other patient between the diagnosis of ovarian cancer (age＜50) and the diagnosis of brain metastasis of ovarian cancer (age=60) is 13 years, providing evidence of the factors influencing the morbidity and prognosis of brain metastasis of ovarian cancer reported in the literature in recent years，and the multimode comprehensive therapy, surgery combined with chemotherapy and radiotherapy can effectively alleviate the symptoms of ovarian cancer and prolong the survival period. We also found that the expression of androgen receptor and BRCA gene mutation were expected to be the landmark events of brain metastasis of ovarian cancer.

Key words: Ovarian neoplasms, Neoplasm metastasis, Radiotherapy, Chemotherapy, adjuvant, Combined modality therapy, Genes, BRCA1, Brain metastasis