关键词: 外泌体, 微RNAs, 卵巢肿瘤

Abstract: The ovarian cancer (OC) mortality rate ranks first among tumors of female reproductive system. Due to lack of early typical symptoms, most patients are diagnosed at advanced stage. Moreover, it is inclined to relapse because of resistance to chemotherapy, resulting in poor prognosis. Therefore, finding effective early diagnosis and treatment is of great significance for early prediction, evaluation, prognosis and recurrence of OC. Exosome is a hotspot in recent years, which is rich in lipids, proteins, RNA and DNA, etc. It is released into the extracellular environment through fusing with cell membranes, affecting the biological behavior of adjacent or distant cells. Furthermore, exosome participates in intercellular communication in the tumor microenvironment and affects the progression of the tumor by transmitting oncogene or tumor suppressor molecules. MicroRNAs (miRNAs) can be encapsulated in exosomes and delivered to recipient cells, playing an important role in tumor progression. This paper reviews the research of exosome miRNAs in OC.

Key words: Exosomes, MicroRNAs, Ovarian neoplasms