关键词: 卵巢肿瘤；, RNA, 长链非编码；, 微RNAs；, 致癌作用；, 生物标记, 肿瘤

Abstract: Ovarian cancer is the leading cause of death among gynecologic malignancies． Since ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and terminal stage. Generally, recurrent drug-resistant tumors and metastasis reduce the efficacy of treatments, therefore more sensitive and efficient diagnostic markers and therapeutic targets need to be discovered and researched. Recently, lncRNAs have been highlighted in oncology researches, showing their potential as an emerging biomarker in the diagnosis and treatment of various human malignancies． In this review, we have summarized several studies about lncRNAs involved in ovarian cancer and analyzed their roles in the tumorigenesis and development of ovarian cancer as well as the interaction between these lncRNAs and related microRNAs in disease progression．

Key words: Ovarian neoplasms;, RNA, long noncoding;, MicroRNAs;, Carcinogenesis;, Biomarkers, tumor